SumMET: Study of [225Ac]Ac-FL-261 in Participants With Solid Tumors Overexpressing c-MET
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This is a first-in-human, multicenter, open-label Phase 1/2 study designed to evaluate the safety, efficacy, and tolerability of \[225Ac\]Ac-FL-261, a targeted radioligand therapy directed at c-MET, in participants with advanced or metastatic solid tumors. Phase 1 will identify the recommended dose through dose escalation, followed by a randomized comparison of two candidate dosing regimens (dose optimization). In Phase 2, the selected dose will be tested in independent cohorts by tumor type.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Podpisana zgoda na udział w badaniu i chęć przejścia wszystkich wymaganych badań
- •Wiek minimum 18 lat
- •Zaawansowany rak, który nie da się wyleczyć operacją, promieniowaniem czy innymi dostępnymi metodami
- •Rak musi być dodatni na białko c-MET (wykazany w laboratorium)
- •Co najmniej jeden widoczny guz do zmierzenia na obrazach (CT, MRI)
- •Dobry ogólny stan zdrowia, zdolny do codziennych aktywności
- •Prawidłowe funkcjonowanie ważnych narządów (serce, wątroba, nerki) w badaniach krwi
- •Kobiety mogące zajść w ciążę: negatywny test ciążowy przed badaniem i przed leczeniem
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- October 16, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (1)
Full-Life Technologies Investigational Site
Nedlands, Australia
Trial contact
Full-Life Technologies
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 10/17/2026.
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