Dose-escalation and Dose-expansion Study of Safety of Azer-cel (PBCAR0191) in Participants With Relapsed/Refractory (r/r) Non-Hodgkin Lymphoma (NHL) and r/r B-cell Acute Lymphoblastic Leukemia (B-ALL)
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This is a Phase 1/1b, nonrandomized, open-label, parallel assignment, dose-escalation, and dose-expansion study to evaluate the safety and clinical activity of azer-cel, an allogeneic anti-CD19 CAR T, in adults with r/r B ALL, r/r B-cell NHL and CLL/SLL.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Potwierdzona nawrotowa lub oporna białaczka limfoblastyczna B-komórkowa (B-ALL) z białkiem CD19
- •Potwierdzona nawrotowa lub oporna chłoniakoma nieziarniczym B-komórkowym (NHL) z białkiem CD19
- •Dla niektórych faz badania: wcześniejsze leczenie innymi terapiami komórkowymi CAR T (maksymalnie 2 linie leczenia)
- •Dla niektórych grup: powinien wykazać odpowiedź na poprzednią terapię CAR T, następnie nawrót choroby
- •Dla niektórych grup: niezdolność do skorzystania z dostępnych autologicznych terapii CAR T
- •Poprzednie leczenie: minimum 1-2 poprzednie linie terapii, maksymalnie 7 linii leczenia systemowego
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- September 8, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (15)
H. Lee Moffitt Cancer Center
Tampa, United States
Winship Cancer Institute Emory University
Atlanta, United States
Northside Hospital Cancer Institute
Atlanta, United States
University of Maryland
Baltimore, United States
Tufts Medical Center
Boston, United States
University of Minnesota
Minneapolis, United States
Columbia University Irving Medical Center/New York Presbyterian Hospital
New York, United States
Lifespan Cancer Institute at Rhode Island Hospital
Providence, United States
Baylor University Medical Center
Dallas, United States
Medical College of Wisconsin
Milwaukee, United States
Royal Prince Alfred Hospital
Camperdown, Australia
Liverpool Hospital
Liverpool, Australia
Royal Adelaide Hospital
Adelaide, Australia
St Vincent's Hospital Melbourne
Fitzroy, Australia
Barwon Health - Andrew Love Cancer Centre
Geelong, Australia
Trial contact
Imugene Clinical Team
Imugene Clinical Team
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 9/9/2026.
You can help another person
We fund the Radar, this site, and the development of our Grosz dla Życia fundraising platform from donations and our own resources. Every contribution, even a small one, really helps.