Targeted Pathway Inhibition in Patients With Pancreatic Cancer
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This early phase I trial aims to determine how cobimetinib, olaparib, onvansertib, azenosertib, AZD5305 or tremelimumab works in patients with pancreatic cancer. Validation of cobimetinib, olaparib, onvansertib azenosertib, AZD5305 and tremelimumab molecular targets will be explored by comparing pre-treatment biopsies with post-treatment specimens. This knowledge will help design future biomarker driven trials to determine whether giving cobimetinib, or olaparib, or onvansertib or azenosertib, or AZD5305, or tremelimumab will work better than standard treatments in patients with pancreatic cancer.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Wiek co najmniej 18 lat
- •Rozpoznany rak trzustki (w różnych stadiach zaawansowania)
- •Chęć i zdolność do podpisania zgody na udział w badaniu
- •Ogólny stan zdrowia pozwalający na udział w badaniu
- •Możliwość pobrania próbki tkanki do badania
- •Wystarczająca liczba zdolnych do transportu tlenu komórek krwi (hemoglobina ≥9,0 g/dL)
- •Wystarczająca liczba białych krwinek (WBC >3 tys./mm³)
- •Wystarczająca liczba neutrofili (ANC ≥1500/mm³)
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- September 4, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (1)
OHSU Knight Cancer Institute
Portland, United States
Trial contact
Charles D. Lopez
Charles D. Lopez
PRINCIPAL_INVESTIGATOR
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 9/5/2026.
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