RMT in Combination With Durvalumab + Chemo in Untreated Adenocarcinoma NSCLC. A Randomized Double Blind Phase II Trial
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This is a randomized, active-controlled, parallel-group, double-blind Phase II trial, of oral restorative microbiota therapy (RMT) or placebo combined with intravenous (IV) durvalumab (MEDI4736) plus chemotherapy in patients with treatment naïve advanced or metastatic adenocarcinoma non-small cell lung cancer (NSCLC)
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Potwierdzony zaawansowany rak płuca (raka adenokarcinoma) w stadium IIIB/C lub IV, bez mutacji EGFR, ALK, ROS1, BRAF, RET, NTRK ani MET
- •Widoczne zmiany nowotworowe możliwe do zmierzenia
- •Dostępne próbki tkanki nowotworowej do badań (minimum 10 skrawków)
- •Znany status PD-L1 (markera w nowotworze)
- •Wcześniejsze chemioterapie lub immunoterapie dopuszczalne tylko jeśli zakończyły się ponad 6 miesięcy temu
- •Pacjenci z przerzutami do mózgu mogą uczestniczyć, jeśli są stabilni i leczenie zakończyło się ponad 2 tygodnie temu
- •Ogólny stan zdrowia: 0 lub 1 w skali ECOG (pacjent jest aktywny)
- •Waga powyżej 30 kg i prawidłowe funkcje narządów wewnętrznych
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- September 17, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (10)
Dr. Amit Kulkarni
Phoenix, United States
MNCCTN Essentia Health St. Joseph's Brainerd Medical Center
Brainerd, United States
MNCCTN Essentia Health Deer River
Deer River, United States
MNCCTN Essentia Health St. Mary's Detroit Lakes Clinic
Detroit Lakes, United States
MNCCTN Essentia Health Duluth
Duluth, United States
MNCCTN Essentia Health Fosston
Fosston, United States
MNCCTN Essentia Health Hibbing Clinic
Hibbing, United States
Masonic Cancer Center, University of Minnesota
Minneapolis, United States
MNCCTN Essentia Health Sandstone
Sandstone, United States
MNCCTN Essentia Health Virginia Clinic
Virginia, United States
Trial contact
Cancer Center Clinical Trials Office
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 9/18/2026.
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