Active, not recruitingPhase IFemale onlyEN originalBreast cancerTriple negative (TNBC)Early / localized

Preoperative Lenvatinib Plus Pembrolizumab in Early-Stage Triple-Negative Breast Cancer (TNBC)

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This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.

This trial is no longer recruiting — here are similar active trials

Matched by cancer type/biomarker, currently recruiting.

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RecruitingPhase III🇵🇱 PolandLung cancerEarly / localized

The main purpose of this study is to evaluate the efficacy of divarasib compared with investigator's choice of immunotherapy (pembrolizumab or nivolumab) or observation in participants with resected Kirsten rat sarcoma viral oncogene homolog glycine 12 to cysteine (KRAS G12C)-positive Stage II-IIIB NSCLC, regardless of tumor programmed death-ligand 1 (PD-L1) status, who have not achieved pathologic complete response (pCR) following neoadjuvant chemoimmunotherapy.

About the trial

This is single arm study of a window of opportunity in which participants with previously untreated triple negative breast cancers (TNBC) who are candidates for potentially curative surgery will receive lenvatinib 12 mg daily for 7 and pembrolizumab 200 mg IV on day 1 prior to surgery

Original English text from ClinicalTrials.gov

Who can (and can't) join

✓ Qualifies

  • •Wiek co najmniej 18 lat
  • •Potwierdzony histologicznie rak piersi (niedrobnokomórkowy), stadium T1b-T3, N0-N3, M0
  • •Kandydat do operacyjnego leczenia radykalnego
  • •Dostępna próbka tkanki z biopsji do badań
  • •Planowana operacja usunięcia guza i węzłów chłonnych po chemioterapii przedoperacyjnej
  • •Rak potrójnie ujemny (brak receptorów estrogenowych, progesteronowych i HER2)
  • •Zadowalająca funkcja narządów wewnętrznych (wątroba, nerki, krew)
  • •Brak przerzutów odległych

Simplified criteria — AI translation

Trial details

Minimum age
18 Years
Last updated (source)
August 28, 2026
Sex
Female only

Therapies / drugs in trial

Locations (1)

University of Illinois

Chicago, United States

Share this trial

Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/1/2026.

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