Targeted Immunotherapy After Myeloablative TBI-Based Conditioning & AlloHCT in CAYA With High Risk T-Cell ALL & Lymphoma
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
A Phase I trial to determine the safety of targeted immunotherapy with daratumumab (DARA) IV after total body irradiation (TBI)-based myeloablative conditioning and allogeneic hematopoietic cell transplantation (HCT) for children, adolescents, and young adults (CAYA) with high risk T-cell acute lymphoblastic leukemia (T-ALL) or T-cell lymphoblastic lymphoma (T-LLy). Pre- and post-HCT NGS-MRD studies will be correlated with outcomes in children, adolescents, and young adults with T-ALL undergoing allogeneic HCT and post-HCT DARA treatment. The study will also evaluate T-cell repertoire and immune reconstitution prior to and following DARA post-HCT treatment and correlate with patient outcomes.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Wiek 0-39 lat
- •Białaczka T-komórkowa w drugiej lub kolejnej remisji (nie więcej niż 5% komórek nowotworowych) lub chłoniak T w pełnej remisji po ponownym leczeniu
- •Planowane przeszczepienie komórek krwiotwórczych od dawcy
- •Ogólny stan zdrowia pozwalający na leczenie (≥60%)
- •W pełni wyzdrowiały po wcześniejszych chemioterapiach lub radioterapii
- •Prawidłowa funkcja organów wewnętrznych
- •Podpisana świadoma zgoda na udział w badaniu
✗ Disqualifies
- •Wcześniejsze przeszczepienie komórek krwiotwórczych
- •Niekontrolowana infekcja w momencie włączenia do badania
- •Alergia na składniki leku daratumumab lub podobnych produktów
- •Ciąża lub karmienie piersią
- •Dodatni wynik na HIV, zapalenie wątroby B lub C
- •Przewlekła obturacyjna choroba płuc (POChP)
- •Astma
- •Poważna choroba serca
Simplified criteria — AI translation
Trial details
- Maximum age
- 39 Years
- Last updated (source)
- September 11, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (16)
Phoenix Children's Hospital
Phoeniz, United States
Loma Linda University Children's Hospital
Loma Linda, United States
University of California
Los Angeles, United States
University of California
San Francisco, United States
Children's Hospital Colordao
Aurora, United States
Children's National Medical Center
Washington D.C., United States
University of Florida
Gainsville, United States
John Hopkins All Children's Hospital
St. Petersburg, United States
Riley Children's Hospital
Indianapolis, United States
Boston Children's Hospital
Boston, United States
Helen DeVos Children's Hospital
Grand Rapids, United States
New York Medical College
Vallhala, United States
Nationwide Children's Hosptial
Columbus, United States
Children's Hospital of Philadelphia
Philadelphia, United States
MD Anderson Cancer Center
Houston, United States
Medical College of Wisconsin
Milwaukee, United States
Trial contact
Lauren Harrison, RN, MSN
Erin Morris, RN
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 9/12/2026.
You can help another person
We fund the Radar, this site, and the development of our Grosz dla Życia fundraising platform from donations and our own resources. Every contribution, even a small one, really helps.