Study Using Prebiotics to Improve Gut Microbiome Diversity After Autologous Cellular Therapy
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
Higher gut microbiome diversity has been associated with improved survival following autologous stem cell transplantation in multiple myeloma and lymphoma. This study hypothesises that prebiotic supplementation with resistant starch (RS) will improve gut microbiome diversity at time of stem cell engraftment. To test this, participants will either have RS or a placebo (maltodextrin) mixed into a food item of their choice for approximately 10 days prior to stem cell infusion and continue to the first day of neutrophil engraftment. The study will look at the difference in gut microbiome diversity between the RS and placebo arm collected at the engraftment timepoint, dietary evaluation to assess the impact of subject diet on microbiome response to intervention and serum sample collection to assess differences to gut permeability during transplant.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Chętny do udziału w badaniu i podpisania zgody
- •Gotowy do wykonania wszystkich procedur badania
- •Potwierdzony nowotwór: szpiczak plazmocytowy, chłoniak nieziarniczy lub chłoniak Hodgkina
- •Zakwalifikowany do przeszczepu komórek macierzystych
- •Wiek co najmniej 19 lat
- •Pierwsza procedura przeszczepu komórek macierzystych
✗ Disqualifies
- •Historia operacji zmniejszającej żołądek
- •Chroniczna choroba przewodu pokarmowego lub zaburzenia absorpcji
- •Wcześniejsze problemy ze strawności rozpuszczalnego włókna
- •Alergia na skrobię ziemniaczaną lub maltodekstrynę
- •Niechętny do zbierania próbek stolca
Simplified criteria — AI translation
Trial details
- Minimum age
- 19 Years
- Last updated (source)
- July 27, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (1)
Unversity of Nebraska Medical Center
Omaha, United States
Trial contact
Jayson Henrickson, MS
Taylor A Johnson, BS, MA
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/28/2026.
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