A Multiple Antigen Vaccine (STEMVAC) for the Treatment of Patients With Stage IV Non-Small Cell Lung Cancer
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This phase II trial tests whether CD105/Yb-1/SOX2/CDH3/MDM2-polyepitope plasmid DNA vaccine (STEMVAC) works to shrink tumors in patients with stage IV non-small cell lung cancer. STEMVAC targets specific immunogenic proteins that help lung cancer cells to grow. STEMVAC is made up of deoxyribonucleic acid (DNA), which is a natural substance in every living organism. DNA acts like a blueprint that tells all the cells in your body how to function. The DNA used in this study contains instructions for your body to produce parts of the 5 proteins the investigators identified (CDH3, CD105, YB-1, MDM2 and SOX2). STEMVAC is given with granulocyte-macrophage colony stimulating factor (GM-CSF) which is being used as an adjuvant to help create a stronger immune response. Giving STEMVAC with GM-CSF to patients while on maintenance therapy for non-small cell lung cancer (NSCLC) may help activate certain immune cells to recognize and kill lung cancer cells.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Potwierdzony diagnoza raka płuca stadium IV
- •Mierzalne ogniska nowotworowe widoczne w badaniach obrazowych
- •Ukończone 3-4 cykle chemioterapii połączonej z immunoterapią bez pogorszenia
- •Otrzymano co najwyżej 2 cykle utrzymującej immunoterapii
- •Co najmniej jedno miejsce w ciele, które można pobrać do badania
- •Ogólny stan zdrowia pozwalający na leczenie (ocena 0-1 w skali ECOG)
- •Oczekiwana długość życia powyżej 6 miesięcy
- •Prawidłowe wyniki badań krwi (liczba białych ciałek, płytek i hemoglobiny)
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- July 27, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (2)
University of Nebraska Medical Center
Omaha, United States
Fred Hutch/University of Washington Cancer Consortium
Seattle, United States
Trial contact
Jennifer Childs
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/28/2026.
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