Neoadjuvant Endocrine Therapy +/- the PI3K Inhibitor Inavolisib in HER2+, HR+, PIK3CA Mutant Early Breast Cancer
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
Evaluation of the potential incremental efficacy and safety of inavolisib in the neoadjuvant endocrine treatment of early-stage HER2-positive, HR-positive, PIK3CA mutant breast cancer.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Pacjent wyraża pisemną zgodę na udział w badaniu.
- •Zdiagnozowano raka piersi (nie leczono wcześniej), potwierdzonego biopsją.
- •Zmiana nowotworowa w piersi jest wystarczająco duża, by ją zmierzyć.
- •Rak piersi jest w początkowym stadium rozwoju (od cT1b do cT3), bez względu na zajęcie węzłów chłonnych.
- •Rak piersi jest pozytywny na białka HER2 i HR (estrogenowe/progesteronowe), a w komórkach guza stwierdzono mutację PIK3CA.
- •Pacjent ma ukończone 18 lat.
- •Ogólny stan zdrowia pacjenta pozwala na udział w badaniu (ECOG 0-1).
- •Serce pacjenta pracuje prawidłowo (potwierdzone EKG i USG serca).
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- September 11, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (62)
KEM Kliniken Essen-Mitte
Essen, Germany
Hämatologie-Onkologie im Zentrum MVZ GmbH
Augsburg, Germany
DBZ Onkologie
Berlin, Germany
Praxisklinik Krebsheilkunde für Frauen
Berlin, Germany
Klinik für Gynäkologie und Geburtshilfe, Brustzentrum/Studiensekretariat
Berlin, Germany
Onkologische Schwerpunktpraxis Bielefeld
Bielefeld, Germany
Klinikum Chemnitz gGmbH
Chemnitz, Germany
Department of Breast-Center Holweide - Kliniken der Stadt Köln
Cologne, Germany
Städtisches Klinikum Dessau
Dessau, Germany
University Hospital Carl Gustav Carus
Dresden, Germany
Gemeinschaftspraxis Haematologie Onkologie
Dresden, Germany
Center for Gynecologic Oncology
Düsseldorf, Germany
Studienzentrale fuer das MVZ Eggenfelden e.K.
Eggenfelden, Germany
Frauenklinik des Universitätsklinikums Erlangen
Erlangen, Germany
Universitätsklinikum Essen
Essen, Germany
Klinik für Gynäkologie und Geburtshilfe Agaplesion Markus Krankenhaus
Frankfurt, Germany
SRH Wald-Klinikum Gera GmbH
Gera, Germany
Mammazentrum HH am Krankenhaus Jerusalem
Hamburg, Germany
Klinikum Hanau
Hanau, Germany
DIAKOVERE Henriettenstift Frauenklinik
Hanover, Germany
National Center for Tumor Diseases - University Hospital Heidelberg
Heidelberg, Germany
Elisabeth Krankenhaus Brustzentrum
Kassel, Germany
Universitätsklinikum Schleswig-Holstein
Kiel, Germany
Praxis für Hämatologie und Onkologie Koblenz and InVo - Institut für Versorgungsforschung in der Onkologie GbR
Koblenz, Germany
University Hospital Mannheim
Mannheim, Germany
University Hospital Gießen and Marburg, Campus Marburg
Marburg, Germany
Media Vita GmbH (MVZ)
Münster, Germany
St. Louise Frauen- und Kinderklinik
Paderborn, Germany
University Hospital Tübingen
Tübingen, Germany
Department of Gynecology and Obstetrics - University of Ulm
Ulm, Germany
GRN Klinik Weinheim
Weinheim, Germany
Klinikum Worms
Worms, Germany
Helios Universitätsklinikum Wuppertal
Wuppertal, Germany
AOSS Antonio e Biagio e Cesare Arrigo
Alessandria, Italy
Università Politecnica delle Marche - Azienda Ospedaliero Universitarià delle Marche
Ancona, Italy
Uo Medicina Oncologica Ospedale Di Carpi
Carpi, Italy
ASST Lecco Ospendale A. Manzoni
Lecco, Italy
AULSS9 Scaligera - Ospedale Mater Salutis di Legnago
Legnago, Italy
Istituto Europeo di Oncologica
Milan, Italy
Instituti Clinici Scientifici Maugeri S.p.A. SB Oncologia Medica
Pavia, Italy
SOC Oncologia S. Maria della Misericordia
Udine, Italy
Ospedale di Circolo e Fondazione Macchi
Varese, Italy
Narodowy Instytut Onkologii
Warsaw, Poland
Spitalul Clinic Filantropia
Bucharest, Romania
Institutul Oncologic "Prof. Dr. Ion Chiricuta"
Cluj-Napoca, Romania
Institutul Regional de Oncologie Iasi
Iași, Romania
Centrul ONCOMED SRI
Timișoara, Romania
Narodny onkologicky ustav
Bratislava, Slovakia
Hospital Clinic of Barcelona Medical Oncology
Barcelona, Spain
Hospital Universitari Vall d´Hebron
Barcelona, Spain
Institut Catalá dÒncologia (ICO)
Barcelona, Spain
Hospital Universitario Clinico San Cecilio Oncology
Granada, Spain
Fundació IRB Lleida Oncología, Unidad de ensayos clínicos
Lleida, Spain
Hospital de Madrid Notre Sanchinarro (CIOCC)
Madrid, Spain
Hospital Universitario 12 de Octubre
Madrid, Spain
Hospital Universitario Ramon y Cajal Servicio de Oncología Médica/ Oficina de Ensayos Clínicos
Madrid, Spain
Hospital General Universitario Morales Meseguer
Murcia, Spain
Hospital Universitario Son Espases
Palma de Mallorca, Spain
Hospital Universitario Marquès de Valdecilla Servicio de Oncologia Medica
Santander, Spain
Hospital Universitario Virgen der Rocio
Seville, Spain
Fundación Instituto Valenciano de Oncología (IVO)
Valencia, Spain
Hospital Clínico Universitario de Valencia
Valencia, Spain
Trial contact
Jana Roßney
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/1/2026.
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