A Phase II Randomized, Open Label Non-inferiority Study of NiraParib Maintenance After 3 vs. 6 Cycles of Platinum-based Chemotherapy in completeLy debUlked Advanced HRDpositive High-grade Ovarian Cancer patientS in First Line Therapy
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
Multicenter, randomized, open label study including patients with advanced HRDpositive high-grade ovarian cancer, fallopian tube cancer, primary peritoneal cancer and clear cell carcinoma of the ovary with no residual tumor mass following primary tumor debulking to determine recurrence free survival in patients treated with 3 cycles carboplatin + paclitaxel and maintenance therapy with niraparib vs. 6 cycles carboplatin + paclitaxel and maintenance therapy with niraparib.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Kobieta w wieku co najmniej 18 lat
- •Zaawansowany rak jajnika, jajowodu, otrzewnej lub rak przejasniowaty jajnika (poza rakiem śluzowym)
- •Całkowite usunięcie guza podczas operacji potwierdzane badaniem CT
- •Obecność określonych zmian genetycznych (mutacja BRCA lub wysoki wynik w teście HRD)
- •Dobry stan ogólny pacjentki (zdolna do codziennych czynności)
- •Możliwość przyjmowania leków doustnie
- •Prawidłowe wyniki badań krwi i funkcji nerek
- •Brak ciąży lub zastosowanie antykoncepcji (dla kobiet w wieku rozrodczym)
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- July 27, 2026
- Sex
- Female only
Therapies / drugs in trial
Locations (50)
Universitätsklinik Innsbruck
Innsbruck, Austria
Cliniques Universitaires St. Luc
Brussels, Belgium
UZ Gent
Ghent, Belgium
Jessa ziekenhuis
Hasselt, Belgium
UZ Leuven
Leuven, Belgium
University Hospital Ostrava
Ostrava, Czechia
General University Hospital in Prague
Prague, Czechia
University Hospital Bulovka
Prague, Czechia
Universitätsklinikum Aachen
Aachen, Germany
Klinikum Mittelbaden Baden-Baden Bühl
Baden-Baden, Germany
DRK-Kliniken Berlin-Köpenick
Berlin, Germany
Charité - Universitätsmedizin Berlin, Campus Virchow Klinikum
Berlin, Germany
ZAHO Bonn Onkologische Praxis
Bonn, Germany
Uniklinikum Bonn
Bonn, Germany
Universitätsklinikum Köln
Cologne, Germany
Klinikum Lippe
Detmold, Germany
Klinikum Dortmund - Klinikum der Universität Witten Herdecke
Dortmund, Germany
Universitätsklinikum Carl Gustav Carus
Dresden, Germany
Florence-Nightingale-Krankenhaus Düsseldorf-Kaiserswerth
Düsseldorf, Germany
Universitätsklinikum Freiburg
Freiburg im Breisgau, Germany
Universitätsklinik Göttingen
Göttingen, Germany
Universitätsklinikum Hamburg-Eppendorf
Hamburg, Germany
SLK-Kliniken Heilbronn
Heilbronn, Germany
Universitätsklinikum Schleswig-Holstein Campus Kiel
Kiel, Germany
Universitätsklinikum Leipzig
Leipzig, Germany
Universitätsklinik der Johannes-Gutenberg Universität Mainz
Mainz, Germany
Klinikum Dritter Orden
München, Germany
Diakonie Klinikum Schwäbisch Hall
Schwäbisch Hall, Germany
Christliches Klinikum Unna Mitte
Unna, Germany
Helios Dr. Horst Schmidt Kliniken Wiesbaden
Wiesbaden, Germany
Policlinico St. Orsola Malpighi
Bologna, Italy
ASST Spedali Civili di Brescia
Brescia, Italy
ASST Lecco - Ospedale A. Manzoni
Lecco, Italy
IRCCS Istituto nazionale dei Tumori
Milan, Italy
AOU Cagliari
Monserrato, Italy
Istituto Oncologico Veneto (IOV)
Padova, Italy
Azienda Ospedaliera Universitaria Pisana
Pisa, Italy
Azienda USL IRCCS Di Reggio Emilia
Reggio Emilia, Italy
AO Ordine Mauriziano
Torino, Italy
AOU Città della Salute e della Scienza di Torino - Ospedale Sant'Anna
Torino, Italy
Hospital General Universitario Dr. Balmis
Alicante, Spain
Hospital Virgen de las Nieves
Granada, Spain
Hospital Universitario Lucus Augusti
Lugo, Spain
CIOCC Clara Campal
Madrid, Spain
H. Althaia Manresa
Manresa, Spain
H.U. Virgen de la Macarena
Seville, Spain
Hospital Universitario Virgen del Rocío
Seville, Spain
Hospital Universitario Sant Joan de Reus
Tarragona, Spain
Hospital General Universitario de Valencia
Valencia, Spain
Hospital La Fe
Valencia, Spain
Trial contact
Jessica Nguyen
Jasmin Yamamoto
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/28/2026.
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