Pre-operative Targeted Treatments in Molecularly Selected Resectable Colorectal Cancer (UNICORN)
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This is a window-of-opportunity umbrella platform trial enrolling non-metastatic resectable colorectal patients selected for the presence of a specific targetable molecular alteration. The study aims to test the activity of specific targeted agents/combinations given as a short-course pre-operative strategy, matched with the specific alteration detected, followed by standard of care surgery.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Wiek 18 lat lub więcej
- •Potwierdzony rozpoznaniem raka jelita grubego, który można całkowicie usunąć operacyjnie
- •Guz w stadium zaawansowanym (T3-4), bez przerzutów do innych narządów
- •Dobrze funkcjonujące nerki, wątroba i szpik kostny
- •Posiadanie fragmentu tkanki guza dostępnego do badania cech genetycznych
- •Wykryta w guzie konkretna zmiana genetyczna kwalifikująca do badania
- •Stan ogólny pacjenta bez poważnych ograniczeń aktywności
- •Brak wcześniejszego leczenia chemioterapią lub radioterapią
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- September 11, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (1)
Fondazione IRCCS Istituto Nazionale dei Tumori di Milano
Milan, Italy
Trial contact
Filippo Pietrantonio, MD
Federica Palermo
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 9/12/2026.
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