Efficacy and Safety of Conventional Neoadjuvant Therapy Versus Total Neoadjuvant Therapy in Older Patients With Locally Advanced Rectal Cancer
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
The SHAPERS study is a multicentre, open-label, randomised, pragmatic clinical trial, comparing standard-of-care neoadjuvant treatment options for older (i.e., ≥70 years) subjects with high-risk stage II and stage III rectal cancer.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Wiek 70 lat lub więcej
- •Potwierdzony rak odbytniczy w zaawansowanym stadium II lub III
- •Nowotwór położony poniżej linii otrzewnej, w odległości do 15 cm od odbytu
- •Dobra funkcja szpiku kostnego, wątroby i nerek
- •Ogólny stan zdrowia pozwalający na leczenie
- •Dobrowolna zgoda na udział w badaniu
✗ Disqualifies
- •Przerzuty nowotworu do innych narządów
- •Wcześniejszy rak odbytniczy
- •Poważne uszkodzenie nerwów obwodowych
- •Rozległy wzrost guza w kość krzyżową (powyżej S2/S3) - nieoperacyjny
Simplified criteria — AI translation
Trial details
- Minimum age
- 70 Years
- Last updated (source)
- August 3, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (19)
ZAS Antwerpen
Antwerp, Belgium
UZA Antwerpen
Edegem, Belgium
AZ Turnhout
Turnhout, Belgium
Institut Jules Bordet
Anderlecht, Belgium
Chirec Delta
Auderghem, Belgium
CHU Saint-Pierre
Brussels, Belgium
CHU Brugmann
Brussels, Belgium
UZ Gent
Ghent, Belgium
AZ Nikolaas
Sint-Niklaas, Belgium
Hôpital de Jolimont
Haine-Saint-Paul, Belgium
Epicura
Hornu, Belgium
CHU Ambroise Pare
Mons, Belgium
CHU de Liège - Sart Tilman
Liège, Belgium
CHA Libramont
Libramont, Belgium
Grand Hôpital De Charleroi
Charleroi, Belgium
CHU Charleroi
Charleroi, Belgium
CHU UCL Namur
Godinne, Belgium
CHR Sambre et Meuse (site Meuse)
Namur, Belgium
CHU St Elisabeth
Namur, Belgium
Trial contact
Sophie Lepannetier, phD
Ikram El Idrissi
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 8/4/2026.
You can help another person
We fund the Radar, this site, and the development of our Grosz dla Życia fundraising platform from donations and our own resources. Every contribution, even a small one, really helps.