AZD3470 as Monotherapy or in Combination With Anticancer Agent(s) in Participants With Haematologic Malignancies.
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This study is designed to evaluate the safety, tolerability, PK, pharmacodynamics, and preliminary efficacy following oral administration of AZD3470 as a monotherapy, and in combination with other anticancer agents in participants with haematologic malignancies.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Wiek co najmniej 18 lat (lub co najmniej 12 lat w części drugiej badania, z minimalną wagą 40 kg)
- •Potwierdzona histologicznie diagnoza chłoniaka Hodgkina lub T-komórkowego
- •Poprzednie leczenie co najmniej 2 liniami terapii bez trwałego efektu (dla chłoniaka Hodgkina: co najmniej 2 serie Brentuximabu i leczenie anty-PD1)
- •Dla pacjentów powyżej 50 lat: osiągnięcie przynajmniej częściowej odpowiedzi na standard pierwszej linii chemioterapii
- •Co najmniej jeden guz możliwy do zmierzenia na obrazowaniu
- •Prawidłowa funkcja narządów i szpiku kostnego
- •Dostarczone próbki tkanki guza do badania
- •Dla niektórych pacjentów: brak białka MTAP w komórkach nowotworowych
Simplified criteria — AI translation
Trial details
- Minimum age
- 12 Years
- Last updated (source)
- October 13, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (38)
Research Site
Duarte, United States
Research Site
Miami, United States
Research Site
Atlanta, United States
Research Site
Boston, United States
Research Site
New York, United States
Research Site
Philadelphia, United States
Research Site
Houston, United States
Research Site
Adelaide, Australia
Research Site
Birtinya, Australia
Research Site
Fitzroy, Australia
Research Site
Nedlands, Australia
Research Site
South Brisbane, Australia
Research Site
Waratah, Australia
Research Site
São Paulo, Brazil
Research Site
São Paulo, Brazil
Research Site
Beijing, China
Research Site
Guangzhou, China
Research Site
Shanghai, China
Research Site
Créteil, France
Research Site
Dijon, France
Research Site
Lille, France
Research Site
Pierre-Bénite, France
Research Site
Villejuif, France
Research Site
Berlin, Germany
Research Site
Cologne, Germany
Research Site
Erlangen, Germany
Research Site
Würzburg, Germany
Research Site
Alessandria, Italy
Research Site
Bologna, Italy
Research Site
Milan, Italy
Research Site
Bunkyō City, Japan
Research Site
Kōtoku, Japan
Research Site
Seoul, South Korea
Research Site
Seoul, South Korea
Research Site
L'Hospitalet de Llobregat, Spain
Research Site
Madrid, Spain
Research Site
Manchester, United Kingdom
Research Site
Oxford, United Kingdom
Trial contact
AstraZeneca Clinical Study Information Center
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 9/15/2026.
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