A Study of CD19 Targeted CAR T Cell Therapy in Pediatric Patients With Relapsed or Refractory B Cell Acute Lymphoblastic Leukemia (B ALL) and Aggressive Mature B-cell Non-Hodgkin Lymphoma (B NHL)
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This is a Phase 1b/2 study to evaluate the safety and efficacy of autologous T cells engineered with a chimeric antigen receptor (CAR) targeting cluster of differentiation (CD)19 in pediatric patients with relapsed or refractory (r/r) B cell acute lymphoblastic leukemia (B ALL) and r/r B cell Non-Hodgkin lymphoma (B NHL).
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Wiek poniżej 18 lat
- •Waga co najmniej 6 kg
- •Rozpoznana białaczka limfoblastyczna typu B, która powróciła lub nie reaguje na leczenie
- •Chłoniak typu B (agresywny), który powrócił lub nie reaguje na leczenie
- •Potwierdzony białaczka lub chłoniak zawiera białko CD19
- •Prawidłowe funkcjonowanie nerek, wątroby, płuc i serca
- •Potwierdzenie CD19 w próbce szpiku, krwi lub płynu mózgowo-rdzeniowego nie starszej niż 30 dni
✗ Disqualifies
- •Białaczka przewlekła w fazie kryzysowej
- •Poważne problemy neurologiczne niezwiązane z rakiem
- •Aktywna infekcja wymagająca intensywnego leczenia
- •Przeszczep szpiku kostnego przeprowadzony mniej niż 3 miesiące temu
- •Wcześniejsze terapie skierowane na CD19 (poza jedną konkretną)
- •Ciężkie powikłania neurologiczne po poprzednim leczeniu
Simplified criteria — AI translation
Trial details
- Minimum age
- 0 Years
- Maximum age
- 18 Years
- Last updated (source)
- October 9, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (14)
Children's Hospital Los Angeles
Los Angeles, United States
Lucile Packard Children's Hospital, Stanford University
Palo Alto, United States
Children's Hospital Colorado
Aurora, United States
Lurie Children's Hospital
Chicago, United States
Cincinnati Children's Hospital
Cincinnati, United States
Children's Hospital of Philadelphia
Philadelphia, United States
Methodist Children's Hospital
San Antonio, United States
Primary Children's Hospital
Salt Lake City, United States
Seattle Children's Hospital
Seattle, United States
Hospital Vall d'Hebron
Barcelona, Spain
Hospital Nino Jesus
Madrid, Spain
Great Ormond Street Hospital for Children NHS Foundation Trust
London, United Kingdom
Royal Manchester Children's Hospital
Manchester, United Kingdom
Great North Children's Hospital
Newcastle upon Tyne, United Kingdom
Trial contact
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 9/17/2026.
You can help another person
We fund the Radar, this site, and the development of our Grosz dla Życia fundraising platform from donations and our own resources. Every contribution, even a small one, really helps.