Open-label Study of BBO-8520 in Adult Subjects With KRASG12C Non-small Cell Lung Cancer
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
A first in human study to evaluate the safety and preliminary antitumor activity of BBO-8520, a KRAS G12C (ON and OFF) inhibitor, as a single agent and in combination with pembrolizumab and BBO-10203 in subjects with locally advanced and unresectable or metastatic non-small cell lung cancer with a KRAS (Kirsten rat sarcoma) G12C mutation.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Potwierdzona histologicznie choroba nowotworowa płuc, która nie może być operowana lub rozprzestrzeniła się na inne części ciała
- •Obecność mutacji genetycznej KRAS G12C w komórkach nowotworu
- •Widoczne ogniska nowotworu możliwe do pomiaru
- •Ogólny stan zdrowia pozwalający na aktywność codzienną (ocena 0-1)
✗ Disqualifies
- •Inne nowotwory w ciągu ostatnich 2 lat
- •Przerzuty do mózgu, które nie były leczone lub są niestabilne
- •Uczulenie na lek BBO-8520 lub jego składniki
- •Dla połączenia z pembrolizumabem: uczulenie na ten lek lub problemy z układem odpornościowym
- •Zapalenie tkanki płucnej w wywiadzie, które wymagało sterydów, lub obecne zapalenie płuc
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- September 3, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (38)
O'Neal Comprehensive Cancer Center at UAB
Birmingham, United States
University of California - San Diego Moores Cancer Center
La Jolla, United States
University of California San Francisco
San Francisco, United States
UCLA Health - Santa Monica Cancer Care
Santa Monica, United States
University of Colorado Cancer Center
Aurora, United States
Yale Cancer Center
New Haven, United States
Norwalk Hospital
Norwalk, United States
OSF Saint Francis Medical Center
Peoria, United States
University of Kansas Medical Center
Kansas City, United States
University of Maryland Marlene & Stewart Greenebaum Comprehensive Cancer Center
Baltimore, United States
Henry Ford Cancer - Detroit
Detroit, United States
Roswell Park Cancer Institute
Buffalo, United States
Perlmutter Cancer Center - NYU Langone Health
New York, United States
Memorial Sloan Kettering Cancer Center
New York, United States
Cleveland Clinic
Cleveland, United States
USOR - Oncology Associates of Oregon, P.C
Eugene, United States
SCRI Oncology Partners
Nashville, United States
Oncology Consultants Texas Medical Center
Houston, United States
USOR - Texas Oncology - (DFW) Waco
Waco, United States
Huntsman Cancer Institute
Salt Lake City, United States
NEXT Oncology
Fairfax, United States
Fred Hutchinson Cancer Center
Seattle, United States
Northwest Medical Specialties
Tacoma, United States
Kinghorn Cancer Centre
Darlinghurst, Australia
Flinders Medical Centre
Bedford Park, Australia
The Queen Elizabeth Hospital
Woodville South, Australia
Peninsula & South Eastern Hematology and Oncology Group (PAS)
Frankston, Australia
Peter MacCallum Cancer Centre
Melbourne, Australia
Linear Clinical Research
Nedlands, Australia
Cross Cancer Institute
Edmonton, Canada
Juravinski Cancer Centre
Hamilton, Canada
The Princess Margaret Cancer Centre
Toronto, Canada
Jewish General Hospital
Montreal, Canada
Rigshospitalet
Copenhagen, Denmark
Vall d'Hebron University Hospital
Horta-Guinardó, Spain
START Barcelona - Hospital HM Nou Delfos
Barcelona, Spain
START Madrid - Hospital Universitario Fundación Jiménez Díaz
Madrid, Spain
Hospital Universitario Quirónsalud Madrid
Madrid, Spain
Trial contact
TheRas, Inc., d/b/a BBOT (BridgeBio Oncology Therapeutics)
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 9/4/2026.
You can help another person
We fund the Radar, this site, and the development of our Grosz dla Życia fundraising platform from donations and our own resources. Every contribution, even a small one, really helps.