Accelerated Brachytherapy Forward Chemo Radiation Therapy (ABC-RT) for Locally-advanced Cervical Cancer
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
The standard treatment for locally advanced cervical cancer is well established as a combination of chemotherapy and radiation, typically over 25-28 daily fractions with the addition of a brachytherapy boost to the primary tumor. An important component to treatment efficacy is overall treatment time. Prolongation of overall treatment time has been shown to lead to worse local control and overall survival; thus, strategies to effectively deliver radiation efficiently is required. This is a pragmatic feasibility study to determine the impact of upfront brachytherapy combined with hypofractionated external beam radiation for patients with locally advanced cervical cancer (FIGO 2018 stage IB3-IVA) on late gastrointestinal and genitourinary toxicity, oncologic outcomes including recurrence free survival, and systemic and local immune response.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Nowodiagnozowany rak szyjki macicy, potwierdzona biopsją, zaawansowana postać (faza IB3-IVA)
- •Typ raka: płaskonabłonkowy, gruczołowy lub mieszany
- •Pacjent zaakceptowany do radioterapii przez lekarza specjalistę
- •Wiek co najmniej 18 lat
- •Stan ogólny pozwalający na podjęcie leczenia
- •Zdolność zrozumienia informacji i podpisania zgody na udział
✗ Disqualifies
- •Wcześniejsza radioterapia miednicy
- •Wcześniejszy inny nowotwór ginekologiczny lub w okolicy miednicy
- •Przerzuty raka poza miednicę
- •Usunięta macica lub planowe usunięcie macicy jako część leczenia
- •Ciąża lub karmienie piersią
- •Duża operacja w ciągu ostatnich 3 tygodni
- •Poważne choroby (niekontrolowane zaburzenia serca, atak serca, trudne do kontroli astma, inne)
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- July 27, 2026
- Sex
- Female only
Therapies / drugs in trial
Locations (1)
Washington University School of Medicine
St Louis, United States
Trial contact
Stephanie Markovina, M.D.
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/28/2026.
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