Intratumoral Delivery of Viral Replicon (saRNA) Particles Expressing IL-12 in Head and Neck Cancer
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
The goal of this clinical trial is to assess the safety and tolerability of a virus replicon particle (VRP) encapsulated saRNA encoding IL-12 when injected into in head and neck cancer patients. The main questions being addressed are: The safety and tolerability of intratumoral (IT) injections of VRP-encapsulated saRNA encoding IL-12 (VLPONC-01) The tumor response to IT injections of VLPONC-01 The tumor response due to the combination of IT injections of VLPONC-01 and system IV administration of neoadjuvant pembrolizumab (anti-PD-1) treatment Researchers will compare neoadjuvant pembrolizumab alone to the combination therapy to see if the combination enhances tumor responses.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Rak głowy i szyi, który nie może być operowany lub wrócił/rozprzestrzenił się, z co najmniej jednym guzikiem do zastrzyku
- •Wcześniejsze leczenie chemioterapią (platyna, fluorouracyl, taksany, cetuximab lub gemcytabina) lub immunoterapią anti-PD-1/PD-L1
- •Potwierdzony postęp choroby po leczeniu inhibitorami punktu kontrolnego PD-1 lub PD-L1
- •Wiek co najmniej 18 lat
- •Dobry ogólny stan zdrowia (ECOG 0-1) i prawidłowe funkcje narządów i szpiku kostnego
- •Guz pierwotny o średnicy większej niż 1 cm, możliwy do zastrzyku
- •Prawidłowe wyniki krwi: neutrofile ≥1500/mcL, płytki ≥100000/mcL, hemoglobina ≥8,0 g/dL
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- September 21, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (1)
Stanford University
Stanford, United States
Trial contact
Clinical Research Coordinator
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 9/22/2026.
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