Enfortumab Vedotin Plus Pembrolizumab With Selective Bladder Sparing for Treatment of Muscle-invasive Bladder Cancer
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
Patients with MIBC will receive 3 cycles (C1-C3) of induction enfortumab vedotin plus pembrolizumab followed by restaging including MRI of the bladder, urine cytology, and cystoscopy with TURBT of any visible tumor and/or resection site plus random biopsies using a recommended template. Patients achieving a stringently defined cCR (clinical complete response) will receive 14 cycles of "maintenance" treatment. Enfortumab vedotin will be administered during the first 6 cycles (C4-C9) of "maintenance" treatment and pembrolizumab will be given all 14 cycles (C4-C14). Patients with any residual disease at clinical restaging (i.e., \>cTa disease) will undergo cystectomy.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Wiek co najmniej 18 lat
- •Diagnoza raka pęcherza moczowego w zaawansowanym stadium (T2-T3), bez przerzutów do węzłów chłonnych
- •Przebyta operacja usunięcia guza z pęcherza (TURBT) w ostatnich 90 dniach
- •Dostępne próbki tkanki tumorowej do badań
- •Stan ogólny pacjenta pozwalający na przeprowadzenie zabiegu chirurgicznego usunięcia pęcherza
- •Prawidłowe wyniki badań laboratoryjnych funkcji narządów
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- August 5, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (5)
City of Hope
Duarte, United States
Indiana University Melvin and Bren Simon Comprehensive Cancer Center
Indianapolis, United States
Icahn School of Medicine at Mount Sinai
New York, United States
Columbia University Irving Medical Center
New York, United States
Fox Chase Cancer Center
Philadelphia, United States
Trial contact
Matthew Galsky, MD
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/29/2026.
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