Testing Addition of an Anti-cancer Drug, Vorasidenib to Temozolomide, After Radiation for Advanced Brain Cancer
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This phase III trial compares the effect of vorasidenib to placebo in combination with usual treatment, temozolomide, in treating patients with newly diagnosed grade 3 astrocytoma after radiation. Temozolomide is in a class of medications called alkylating agents. It works by damaging the cell's deoxyribonucleic acid and may kill tumor cells and slow down or stop tumor growth. Vorasidenib citrate blocks the proteins made by the mutated IDH1 and IDH2 genes, which may help keep tumor cells from growing. It is a type of enzyme inhibitor and a type of targeted therapy. Adding vorasidenib to the usual treatment, temozolomide, may be more effective than temozolomide alone in treating patients with newly diagnosed grade 3 astrocytoma after radiation therapy.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Diagnoza glejaka (astrocytoma) typu IDH-mutant, stopień 3.
- •Rak mózgu z potwierdzonymi specyficznymi mutacjami genetycznymi (IDH1 lub IDH2).
- •Brak usunięcia całego ramienia chromosomu 1p/19q (ważne dla określenia typu raka).
- •Brak przerzutów do rdzenia kręgowego lub opon mózgowo-rdzeniowych.
- •Pacjent nie przyjmował wcześniej chemioterapii ani innych celowanych terapii.
- •Wszczepienie lub biopsja wykonana nie wcześniej niż 6 miesięcy przed rozpoczęciem badania.
- •Zaplanowana radioterapia i późniejsza chemioterapia.
- •Wiek od 12 lat wzwyż.
✗ Disqualifies
- •Rak mózgu, który nie ma mutacji IDH.
- •Współistniejące inne poważne choroby, które mogą wpłynąć na wyniki leczenia.
- •Niewydolność narządów (np. wątroby, nerek) w znacznym stopniu.
- •Niewystarczające wyniki badań krwi (np. niskie białe krwinki, płytki krwi).
Simplified criteria — AI translation
Trial details
- Minimum age
- 12 Years
- Last updated (source)
- October 2, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (152)
AIS Cancer Center at San Joaquin Community Hospital
Bakersfield, United States
City of Hope Comprehensive Cancer Center
Duarte, United States
Kaiser Permanente Dublin
Dublin, United States
Kaiser Permanente-Fremont
Fremont, United States
Kaiser Permanente Fresno Orchard Plaza
Fresno, United States
Kaiser Permanente-Fresno
Fresno, United States
UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care
Irvine, United States
Kaiser Permanente- Modesto MOB II
Modesto, United States
Kaiser Permanente-Oakland
Oakland, United States
UC Irvine Health/Chao Family Comprehensive Cancer Center
Orange, United States
Kaiser Permanente-Roseville
Roseville, United States
Kaiser Permanente Downtown Commons
Sacramento, United States
University of California Davis Comprehensive Cancer Center
Sacramento, United States
Kaiser Permanente-South Sacramento
Sacramento, United States
Kaiser Permanente-San Francisco
San Francisco, United States
Kaiser Permanente-Santa Teresa-San Jose
San Jose, United States
Kaiser Permanente San Leandro
San Leandro, United States
Kaiser San Rafael-Gallinas
San Rafael, United States
Kaiser Permanente Medical Center - Santa Clara
Santa Clara, United States
Kaiser Permanente-Santa Rosa
Santa Rosa, United States
Kaiser Permanente-South San Francisco
South San Francisco, United States
Kaiser Permanente-Vallejo
Vallejo, United States
Kaiser Permanente-Walnut Creek
Walnut Creek, United States
John Muir Medical Center-Walnut Creek
Walnut Creek, United States
Yale University
New Haven, United States
Smilow Cancer Hospital Care Center-Trumbull
Trumbull, United States
Smilow Cancer Hospital Care Center - Waterford
Waterford, United States
Helen F Graham Cancer Center
Newark, United States
Medical Oncology Hematology Consultants PA
Newark, United States
UM Sylvester Comprehensive Cancer Center at Coral Gables
Coral Gables, United States
UM Sylvester Comprehensive Cancer Center at Coral Springs
Coral Springs, United States
UM Sylvester Comprehensive Cancer Center at Deerfield Beach
Deerfield Beach, United States
UM Sylvester Comprehensive Cancer Center at Doral
Doral, United States
UM Sylvester Comprehensive Cancer Center at Hollywood
Hollywood, United States
University of Miami Miller School of Medicine-Sylvester Cancer Center
Miami, United States
UM Sylvester Comprehensive Cancer Center at Kendall
Miami, United States
University of Miami Sylvester Comprehensive Cancer Center at Sole Mia
North Miami, United States
UM Sylvester Comprehensive Cancer Center at Plantation
Plantation, United States
Augusta University Medical Center
Augusta, United States
OSF Saint Joseph Medical Center
Bloomington, United States
Illinois CancerCare-Bloomington
Bloomington, United States
Illinois CancerCare-Canton
Canton, United States
Illinois CancerCare-Carthage
Carthage, United States
University of Illinois
Chicago, United States
Illinois CancerCare-Eureka
Eureka, United States
NorthShore University HealthSystem-Evanston Hospital
Evanston, United States
Illinois CancerCare-Galesburg
Galesburg, United States
NorthShore University HealthSystem-Glenbrook Hospital
Glenview, United States
NorthShore University HealthSystem-Highland Park Hospital
Highland Park, United States
Illinois CancerCare-Kewanee Clinic
Kewanee, United States
Illinois CancerCare-Macomb
Macomb, United States
Illinois CancerCare-Ottawa Clinic
Ottawa, United States
Illinois CancerCare-Pekin
Pekin, United States
Illinois CancerCare-Peoria
Peoria, United States
OSF Saint Francis Radiation Oncology at Peoria Cancer Center
Peoria, United States
OSF Saint Francis Medical Center
Peoria, United States
Illinois CancerCare-Peru
Peru, United States
Illinois CancerCare-Princeton
Princeton, United States
Illinois CancerCare - Washington
Washington, United States
Midwestern Regional Medical Center
Zion, United States
UI Health Care Mission Cancer and Blood - Ankeny Clinic
Ankeny, United States
UI Health Care Mission Cancer and Blood - West Des Moines Clinic
Clive, United States
Iowa Methodist Medical Center
Des Moines, United States
UI Health Care Mission Cancer and Blood - Des Moines Clinic
Des Moines, United States
Broadlawns Medical Center
Des Moines, United States
Mercy Medical Center - Des Moines
Des Moines, United States
UI Health Care Mission Cancer and Blood - Laurel Clinic
Des Moines, United States
UI Healthcare Mission Cancer and Blood - Pella
Pella, United States
UI Health Care Mission Cancer and Blood - Waukee Clinic
Waukee, United States
University of Kansas Cancer Center
Kansas City, United States
Lawrence Memorial Hospital
Lawrence, United States
University of Kansas Cancer Center-Overland Park
Overland Park, United States
University of Kansas Hospital-Indian Creek Campus
Overland Park, United States
University of Kansas Hospital-Westwood Cancer Center
Westwood, United States
The James Graham Brown Cancer Center at University of Louisville
Louisville, United States
UofL Health Medical Center Northeast
Louisville, United States
West Jefferson Medical Center
Marrero, United States
East Jefferson General Hospital
Metairie, United States
University Medical Center New Orleans
New Orleans, United States
Children's Hospital New Orleans
New Orleans, United States
MaineHealth Coastal Cancer Treatment Center
Bath, United States
MaineHealth Maine Medical Center - Portland
Portland, United States
MaineHealth Cancer Care Center of York County
Sanford, United States
MaineHealth Maine Medical Center- Scarborough
Scarborough, United States
Tufts Medical Center
Boston, United States
Massachusetts General Hospital Cancer Center
Boston, United States
Dana-Farber Cancer Institute
Boston, United States
University of Michigan Rogel Cancer Center
Ann Arbor, United States
University of Michigan - Brighton Center for Specialty Care
Brighton, United States
Corewell Health Grand Rapids Hospitals - Butterworth Hospital
Grand Rapids, United States
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital
Grand Rapids, United States
Trinity Health Grand Rapids Hospital
Grand Rapids, United States
University of Michigan Health - West
Wyoming, United States
Mercy Hospital
Coon Rapids, United States
Fairview Southdale Hospital
Edina, United States
Abbott-Northwestern Hospital
Minneapolis, United States
Coborn Cancer Center at Saint Cloud Hospital
Saint Cloud, United States
Regions Hospital
Saint Paul, United States
United Hospital
Saint Paul, United States
University of Mississippi Medical Center
Jackson, United States
Siteman Cancer Center at Saint Peters Hospital
City of Saint Peters, United States
Siteman Cancer Center at West County Hospital
Creve Coeur, United States
University of Kansas Cancer Center - Briarcliff
Kansas City, United States
University of Kansas Cancer Center - North
Kansas City, United States
University of Kansas Cancer Center - Lee's Summit
Lee's Summit, United States
Mercy Hospital Springfield
Springfield, United States
Washington University School of Medicine
St Louis, United States
Siteman Cancer Center-South County
St Louis, United States
Siteman Cancer Center at Christian Hospital
St Louis, United States
Memorial Sloan Kettering Basking Ridge
Basking Ridge, United States
Hackensack University Medical Center
Hackensack, United States
Memorial Sloan Kettering Monmouth
Middletown, United States
Memorial Sloan Kettering Bergen
Montvale, United States
Northwell Health Imbert Cancer Center
Bay Shore, United States
NYU Langone Hospital - Brooklyn
Brooklyn, United States
Memorial Sloan Kettering Commack
Commack, United States
Memorial Sloan Kettering Westchester
Harrison, United States
Northwell Health/Center for Advanced Medicine
Lake Success, United States
NYU Langone Hospital - Long Island
Mineola, United States
Northern Westchester Hospital
Mount Kisco, United States
Laura and Isaac Perlmutter Cancer Center at NYU Langone
New York, United States
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
New York, United States
Memorial Sloan Kettering Cancer Center
New York, United States
Stony Brook University Medical Center
Stony Brook, United States
Memorial Sloan Kettering Nassau
Uniondale, United States
University of Cincinnati Cancer Center-UC Medical Center
Cincinnati, United States
Ohio State University Comprehensive Cancer Center
Columbus, United States
University of Cincinnati Cancer Center-West Chester
West Chester, United States
University of Oklahoma Health Sciences Center
Oklahoma City, United States
Providence Portland Medical Center
Portland, United States
Providence Saint Vincent Medical Center
Portland, United States
Christiana Care Health System-Concord Health Center
Chadds Ford, United States
UPMC Hillman Cancer Center Erie
Erie, United States
Forbes Hospital
Monroeville, United States
Thomas Jefferson University Hospital
Philadelphia, United States
Allegheny General Hospital
Pittsburgh, United States
UPMC Hillman Cancer Center
Pittsburgh, United States
UPMC-Shadyside Hospital
Pittsburgh, United States
Wexford Health and Wellness Pavilion
Wexford, United States
Medical University of South Carolina
Charleston, United States
Huntsman Cancer Institute/University of Utah
Salt Lake City, United States
University of Vermont Medical Center
Burlington, United States
University of Vermont and State Agricultural College
Burlington, United States
Swedish Medical Center-First Hill
Seattle, United States
Froedtert Menomonee Falls Hospital
Menomonee Falls, United States
Medical College of Wisconsin
Milwaukee, United States
ProHealth D N Greenwald Center
Mukwonago, United States
Froedtert and MCW Moorland Reserve Health Center
New Berlin, United States
Drexel Town Square Health Center
Oak Creek, United States
ProHealth Oconomowoc Memorial Hospital
Oconomowoc, United States
UW Cancer Center at ProHealth Care
Waukesha, United States
Froedtert West Bend Hospital/Kraemer Cancer Center
West Bend, United States
Trial contact
Alexandra Alexandra LeVasseur
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/3/2026.
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