A Phase 1b Study of Lonitoclax + Azacitidine in Acute Myeloid Leukemia Patients
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This is a clinical study aiming to evaluate the safety, pharmacokinetics, pharmacodynamics, and preliminary efficacy of ZE50-0134 in relapsed and refractory Acute Myeloid Leukemia patients.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Wiek 18 lat lub więcej
- •Rozpoznana ostra białaczka szpikowa, która nie odpowiada na leczenie lub wróciła
- •Pacjent może wcześniej otrzymywać określone leki (hipometylujące lub Venetoclax)
- •Liczba białych krwinek poniżej 25 × 10⁹/L (w razie potrzeby można jej obniżyć lekiem)
- •Ogólny stan zdrowia pozwalający na aktywność minimum kilka godzin dziennie
- •Prawidłowa funkcja wątroby i nerek
- •Kobiety: gotowość używania skutecznej antykoncepcji przez 120 dni po ostatniej dawce leku
- •Zdolność zrozumienia i podpisania świadomej zgody
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- August 31, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (6)
State Budgetary Institution of Healthcare S.P. Botkin Moscow Multidisciplinary Scientific and Clinical Center of the Moscow Health Department
Moscow, Russia
Medsi group Joint Stock Company Clinical Hospital
Krasnogorsk, Russia
State Regional Budgetary Healthcare Institution "Novgorod Regional Clinical Hospital"
Velikiy Novgorod, Russia
Federal State Budgetary Institution "Russian Research Institute of Hematology and Transfusiology of the Federal Medical and Biological Agency"
Saint Petersburg, Russia
State Budgetary Healthcare Institution Leningrad Regional Clinical Hospital
Saint Petersburg, Russia
Republican Specialized Scientific and Practical Medical Center of Hematology of the Ministry of Health
Tashkent, Uzbekistan
Trial contact
Ekaterina Dokukina
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 9/1/2026.
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