Symbiotic-GU-06: A Study to Learn About PF-08634404 Alone or In Combination With Enfortumab Vedotin in Urothelial Cancer
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This study is being done to learn more about a new medicine called PF-08634404. It is for adults with a type of bladder cancer called locally advanced or metastatic urothelial cancer (LA/mUC), meaning the cancer has spread to nearby tissues or other parts of the body. The purpose of the study is to see if PF-08634404 is safe, how well it works, how it moves through the body, and how it affects the cancer. The study will also look at how the medicine may change certain markers in the body that are linked to cancer. To join the study, participants must: * Be adults (18 years or older) and * Have locally advanced or metastatic urothelial cancer, The study has two groups: * Cohort A: People who have already received treatment for their cancer will get the study medicine ( PF-08634404) alone. * Cohort B: People who have not had treatment before will get the study medicine along with another cancer medicine called enfortumab vedotin. Everyone in the study will get the study medicine through a vein (IV infusion) with or without enfortumab vedotin. Treatment will continue as long as it helps and side effects are manageable. Before starting, participants will go through a screening period to check if they are eligible. During the study, they will have regular visits for treatment, health checks, and tests to see how the cancer is responding. Scans will be done regularly to monitor the cancer. If the cancer gets worse but the treatment is still helping and side effects are manageable, participants may be allowed to continue treatment with their doctor's and the sponsor's agreement.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Wiek co najmniej 18 lat
- •Potwierdzony rozpoznaniem rak pęcherza moczowego, który rozprzestrzeniął się
- •Widoczne zmiany nowotworu widoczne w badaniach obrazowych
- •Ogólny stan zdrowia pozwalający na uczestnictwo w badaniu (ocena 0-1)
- •Prawidłowe funkcjonowanie nerek, wątroby i krwi
- •Zgoda na stosowanie antykoncepcji (osoby w wieku rozrodczym)
- •Zdolność i chęć do uczestniczenia w badaniu
✗ Disqualifies
- •Inny rak zdiagnozowany w ciągu ostatnich 3 lat
- •Przerzuty nowotworu do mózgu lub rdzenia kręgowego
- •Aktywna choroba autoimmunologiczna wymagająca leczenia
- •Uczestnictwo w innym badaniu klinicznym w ciągu ostatniego miesiąca
- •Ciąża lub karmienie piersią
- •Brak możliwości lub chęci do uczestniczenia w badaniu
- •Pracownik lub bliski członek rodziny pracownika badania
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- October 8, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (184)
Highlands Oncology Group, PA
Fayetteville, United States
Highlands Oncology Group, PA
Rogers, United States
Highlands Oncology Group, PA
Springdale, United States
UCLA Hematology/Oncology - Alhambra
Alhambra, United States
UCLA Hematology/Oncology - Atascadero
Atascadero, United States
UCLA Hematology/Oncology - Beverly Hills
Beverly Hills, United States
UCLA Hematology/Oncology - Burbank
Burbank, United States
City of Hope (City of Hope National Medical Center, City of Hope Medical Center)
Duarte, United States
City of Hope Investigational Drug Services (IDS)
Duarte, United States
UC San Diego Medical Center - Encinitas
Encinitas, United States
UCLA Hematology/Oncology - Encino
Encino, United States
UCLA Hematology/Oncology - Irvine
Irvine, United States
Chao Family Comprehensive Cancer Center and Ambulatory Care
Irvine, United States
UCI Health - Irvine Infusion Pharmacy ACC
Irvine, United States
City of Hope at Irvine Lennar
Irvine, United States
City of Hope Investigational Drug Service (IDS)
Irvine, United States
UC San Diego Koman Family Outpatient Pavilion
La Jolla, United States
UC San Diego Medical Center - La Jolla (Jacobs Medical Center / Thornton Pavilion)
La Jolla, United States
UC San Diego Moores Cancer Center
La Jolla, United States
UC San Diego Shiley Eye Institute
La Jolla, United States
UC San Diego Sulpizio Cardiovascular Center
La Jolla, United States
Viterbi Family Department of Ophthalmology
La Jolla, United States
UCLA Hematology Oncology- Laguna Hills
Laguna Hills, United States
City of Hope-Long Beach (ELM)
Long Beach, United States
START Los Angeles, LLC
Los Angeles, United States
Los Angeles Cancer Network - Century City
Los Angeles, United States
(IRB# 26-0433) Ronald Reagan UCLA Medical Center, Drug Information Center
Los Angeles, United States
UCLA Hematology/Oncology
Los Angeles, United States
UCLA Hematology/Oncology - Marina del Rey
Marina del Rey, United States
UC Irvine Health
Orange, United States
UCLA Hematology/Oncology - Pasadena
Pasadena, United States
UCLA Hematology Oncology - Porter Ranch
Porter Ranch, United States
UC San Diego Medical Center - Bankers Hill
San Diego, United States
UC San Diego McGrath Outpatient Pavilion - Hillcrest
San Diego, United States
UC San Diego Medical Center- Hillcrest
San Diego, United States
UC San Diego Medical Center - Rancho Bernardo
San Diego, United States
UCLA Hematology/Oncology - San Luis Obispo
San Luis Obispo, United States
UCLA Hematology/Oncology- Santa Barbara
Santa Barbara, United States
UCLA Hematology/Oncology- Santa Monica
Santa Monica, United States
UCLA Hematology/Oncology - Torrance
Torrance, United States
City of Hope UPLAND
Upland, United States
UCLA Hematology/Oncology - Santa Clarita
Valencia, United States
UCLA Hematology/Oncology - Ventura
Ventura, United States
UC San Diego Medical Center - Vista
Vista, United States
UCLA Hematology/Oncology - Westlake
Westlake Village, United States
Rocky Mountain Cancer Centers, LLP
Aurora, United States
Rocky Mountain Cancer Centers, LLP
Denver, United States
Rocky Mountain Cancer Centers, LLP
Lone Tree, United States
Smilow Cancer Hospital - Derby
Derby, United States
Smilow Cancer Hospital - Fairfield
Fairfield, United States
Smilow Cancer Hospital - Greenwich
Greenwich, United States
Smilow Cancer Hospital - Guilford
Guilford, United States
Smilow Cancer Hospital - Yale New Haven Health
New Haven, United States
Yale Eye Center
New Haven, United States
Yale-New Haven Hospital-Yale Cancer Center
New Haven, United States
Smilow Cancer Hospital Phase 1 Unit
New Haven, United States
Yale University - Smilow Cancer Hospital; C/O Thomas Ferencz, RPh, BCOP
New Haven, United States
Smilow Cancer Hospital - North Haven
North Haven, United States
Eastern Connecticut Hematology and Oncology Associates
Norwich, United States
Smilow Cancer Hospital - Long Ridge
Stamford, United States
Smilow Cancer Hospital - Trumbull
Trumbull, United States
Sibley Memorial Hospital Pharmacy Department
Washington D.C., United States
Sibley Memorial Hospital
Washington D.C., United States
Tennessee Oncology, PLLC- Ringgold
Ringgold, United States
Memorial Hospital
Shiloh, United States
Siteman Cancer Center - Shiloh
Shiloh, United States
Oncology Research Pharmacy and lnvestigational Drug Service
Baltimore, United States
The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Baltimore, United States
Johns Hopkins Hospital
Baltimore, United States
Johns Hopkins Outpatient Center
Baltimore, United States
The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Baltimore, United States
Siteman Cancer Center - St. Peters
City of Saint Peters, United States
Siteman Cancer Center - West County
Creve Coeur, United States
Siteman Cancer Center - North County
Florissant, United States
Siteman Cancer Center
St Louis, United States
Barnes-Jewish Hospital
St Louis, United States
Washington University School of Medicine - Siteman Cancer Center
St Louis, United States
Siteman Cancer Center - South County
St Louis, United States
MSK Basking Ridge
Basking Ridge, United States
MSK Monmouth
Middletown, United States
MSK Bergen
Montvale, United States
New York Oncology Hematology
Albany, United States
New York Oncology Hematology
Clifton Park, United States
MSK Commack
Commack, United States
MSK Westchester
Harrison, United States
Investigational Drug Service
Long Island City, United States
Memorial Sloan Kettering Cancer Center - David H. Koch Center for Cancer Care (74th Street).
New York, United States
Icahn School of Medicine at Mount Sinai
New York, United States
Evelyn H. Lauder Breast and Imaging Center (BAIC)
New York, United States
Memorial Sloan Kettering Cancer Center-Main Campus
New York, United States
Sidney Kimmel Center for Prostate and Urological Cancers - Memorial Sloan Kettering Cancer Center
New York, United States
MSK Nassau
Uniondale, United States
Duke Cancer Center Cary
Cary, United States
Duke University Medical Center (location of scans)
Durham, United States
Duke University Medical Center - Duke University Hospital (location of scans)
Durham, United States
Duke University Medical Center
Durham, United States
Duke University
Durham, United States
Duke Cancer Center Raleigh
Raleigh, United States
Duke Raleigh Hospital
Raleigh, United States
Duke Women's Cancer Care Raleigh (Pharmacy location and location of CT, MRI and Bone scan machines)
Raleigh, United States
University Hospitals Cleveland Medical Center
Cleveland, United States
Cleveland Clinic Foundation
Cleveland, United States
Cleveland Clinic Taussig Cancer Center Investigational Pharmacy
Cleveland, United States
Oncology Associates of Oregon, P.C.
Eugene, United States
Northwest Cancer Specialists, P.C.
Portland, United States
Northwest Cancer Specialists, P.C.
Portland, United States
Oncology Associates of Oregon, P.C.
Springfield, United States
Northwest Cancer Specialists, P.C.
Tigard, United States
Tennessee Oncology, PLLC - Chattanooga Downtown
Chattanooga, United States
Tennessee Oncology, PLLC - Chattanooga Med Park II
Chattanooga, United States
Tennessee Oncology, PLLC - Chattanooga Memorial
Chattanooga, United States
Tennessee Oncology, PLLC - Investigational Drug Services/Supply Storage
Chattanooga, United States
Tennessee Oncology, PLLC - Chattanooga East
Chattanooga, United States
Tennessee Oncology, PLLC- Cookeville
Cookeville, United States
Tennessee Oncology, PLLC - Dickson
Dickson, United States
Tennessee Oncology, PLLC - Franklin
Franklin, United States
Tennessee Oncology, PLLC - Proton Center
Franklin, United States
Tennessee Oncology, PLLC - Gallatin
Gallatin, United States
Tennessee Oncology, PLLC - Hendersonville
Hendersonville, United States
Tennessee Oncology, PLLC - Lebanon
Lebanon, United States
Tennessee Oncology, PLLC - Mount Juliet
Mount Juliet, United States
Tennessee Oncology, PLLC - Murfreesboro
Murfreesboro, United States
Sarah Cannon Research Institute
Nashville, United States
SCRI Oncology Partners
Nashville, United States
Tennessee Oncology, PLLC - Elliston Place Plaza Medical Oncology & Hematology
Nashville, United States
Tennessee Oncology, PLLC - Investigational Drug Services
Nashville, United States
Tennessee Oncology, PLLC - Saint Thomas West
Nashville, United States
Tennessee Oncology, PLLC- Skyline
Nashville, United States
Tennessee Oncology, PLLC- Southern Hills
Nashville, United States
Tennessee Oncology, PLLC -Shelbyville
Shelbyville, United States
Tennessee Oncology, PLLC - Smyrna
Smyrna, United States
Texas Oncology - Central/South Texas
Austin, United States
Texas Oncology - Central/South Texas
Austin, United States
Texas Oncology - Central/South Texas
Austin, United States
Texas Oncology - Gulf Coast
Beaumont, United States
Texas Oncology - Central/South Texas
Harlingen, United States
Texas Oncology - Gulf Coast
Houston, United States
Texas Oncology - Gulf Coast
Houston, United States
US Oncology Investigational Product Center (IPC)
Irving, United States
US Oncology Investigational Products Center (IPC)
Irving, United States
Texas Oncology - Central/South Texas
McAllen, United States
Texas Oncology - Gulf Coast
Pearland, United States
Texas Oncology - Gulf Coast
Sugar Land, United States
Texas Oncology - Gulf Coast
The Woodlands, United States
Texas Oncology - Central/South Texas
Waco, United States
Texas Oncology - Gulf Coast
Webster, United States
Texas Oncology - Central South
Weslaco, United States
Huntsman Cancer Institute - University of Utah
Salt Lake City, United States
Oncology & Hematology Associates of Southwest Virginia, Inc.,DBA Blue Ridge Cancer Care
Blacksburg, United States
Virginia Cancer Specialists, PC
Fairfax, United States
Oncology & Hematology Associates of Southwest Virginia, Inc.,DBA Blue Ridge Cancer Care
Low Moor, United States
Virginia Oncology Associates
Norfolk, United States
Oncology & Hematology Associates of Southwest Virginia, Inc.,DBA Blue Ridge Cancer Care
Roanoke, United States
Oncology & Hematology Associates of Southwest Virginia, Inc.,DBA Blue Ridge Cancer Care
Salem, United States
Oncology & Hematology Associates of Southwest Virginia, Inc.,DBA Blue Ridge Cancer Care
Wytheville, United States
Eye Associates Northwest - Edmonds Clinic
Edmonds, United States
Eye Associates Northwest - Kirkland Clinic
Kirkland, United States
Eye Associates Northwest - Ballard Clinic and Surgery Center
Seattle, United States
Eye Associates Northwest - First Hill Clinic
Seattle, United States
Harborview Medical Center
Seattle, United States
Fred Hutchinson Cancer Center
Seattle, United States
Eye Associates Northwest - Northgate Clinic
Seattle, United States
University Of Washington Medical Center
Seattle, United States
Northwest Cancer Specialists, P.C.
Vancouver, United States
Macquarie University
North Ryde, Australia
Icon Cancer Centre Wesley
Auchenflower, Australia
Monash Health
Clayton, Australia
Beijing Cancer hospital
Beijing, China
Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School
Nanjing, China
The Second Hospital of Tianjin Medical University
Tianjin, China
The first affiliated hospital of Ningbo university
Ningbo, China
Keio university hospital
Shinjuku-ku, Japan
National Hospital Organization Kyushu Cancer Center
Fukuoka, Japan
Yamagata University Hospital
Yamagata, Japan
Pan American Center for Oncology Trials, LLC - Manati Office
Manati, Puerto Rico
Pan American Center for Oncology Trials, LLC - Mayaguez Office
Mayagüez, Puerto Rico
Hospital Oncologico Dr. Isaac Gonzalez-Martinez
Rio Piedras, Puerto Rico
Pan American Center for Oncology Trials, LLC
Rio Piedras, Puerto Rico
Parc de Salut Mar - Hospital del Mar
Barcelona, Spain
Hospital Universitari Vall d'Hebron
Barcelona, Spain
Hospital Universitario Marqués de Valdecilla
Santander, Spain
Hospital de la Santa Creu i Sant Pau
Barcelona, Spain
Hospital Universitario 12 de Octubre
Madrid, Spain
Hospital Universitario Virgen Del Rocio
Seville, Spain
Trial contact
Pfizer CT.gov Call Center
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/9/2026.
You can help another person
We fund the Radar, this site, and the development of our Grosz dla Życia fundraising platform from donations and our own resources. Every contribution, even a small one, really helps.