Pre-Radiation Chemotherapy for Newly Diagnosed High-Grade Glioma.
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
Better treatments are needed for high-grade gliomas (HGG), and new ways of treating this disease should be tested. The investigators want to see if giving medicine before radiation works well. After radiation, MRI scans can be harder to understand because radiation changes how the brain looks on the scan. If new medicines are given before radiation, the scans are easier to read. First, the investigators need to find out if giving chemotherapy early works using a drug we already know can treat gliomas. The investigators will start with temozolomide, which is the only chemotherapy approved by the FDA for HGG. If this approach is successful, the investigators can then test new drugs using this screening method.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Potwierdzona histopatologicznie diagnoza glejaka wysokiego stopnia
- •Możliwy do zmierzenia guz po operacji
- •Wiek 18-80 lat
- •Dobry ogólny stan zdrowia (Karnofsky ≥70%)
- •Zdolność do przyjmowania leków doustnych i stosowania się do planu badania
- •Prawidłowe wyniki badań krwi (liczba płytek, hemoglobina, wątróba, nerki)
- •Kobiety w wieku rozrodczym muszą stosować skuteczną antykoncepcję
- •Mężczyźni muszą stosować prezerwatywy lub inną skuteczną antykoncepcję
✗ Disqualifies
- •Uczestnictwo w innym badaniu z testowaniem nowych leków
- •Implantacja wstawki Gliadel lub innej lokalnej terapii w guzie
- •Alergia na temozolomid lub podobne leki
- •Niekontrolowana infekcja lub poważne problemy psychiczne
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Maximum age
- 80 Years
- Last updated (source)
- October 9, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (1)
Cooper University HealthCare
Camden, United States
Trial contact
Cooper Research Team
Danielle Bazer
PRINCIPAL_INVESTIGATOR
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 10/10/2026.
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