Bendamustine Versus Fludarabine/Cyclophosphamide for Lymphodepletion in Chimeric Antigen Receptor T-cell Immunotherapy (CAR-T): a Randomized Trial.
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
Bendamustine and the combination of fludarabine/cyclophosphamide are fully authorized chemotherapy agents in Switzerland for lymphoma treatment and currently used in routine clinical practice as lymphodepletion strategy before CAR-T immunotherapy, as supported by retrospective studies and clinical experience across multiple centers. None of the drugs described in this protocol are being used at unapproved doses, or in an investigational formulation. Both lymphodepletion regimens have a known safety profile and the risks and burdens imposed on participants do not exceed those encountered in routine CAR-T therapy management, as all procedures (including monitoring, supportive care, and follow-up assessments) align with standard clinical practice. Based on these assumptions, this protocol is designed to investigate the use of bendamustine as an alternative lymphodepletion therapy (which is a part of CAR-T immunotherapy protocol).
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Rozpoznanie dużokomórkowego chłoniaka z komórek B, który wcześniej był leczony
- •Kwalifikacja do komercyjnej terapii CAR-T według lekarza
- •Wiek co najmniej 18 lat
- •Możliwość podpisania świadomej zgody na udział w badaniu
✗ Disqualifies
- •Stosowanie innego eksperymentalnego leku w ciągu ostatnich 4 tygodni
- •Bendamustyna podawana w ciągu 3 miesięcy przed pobraniem komórek
- •Poprzednia terapia CAR-T skierowana na CD19 w ciągu ostatnich 12 miesięcy
- •Uczulenie na bendamustynę, fludarabinę, cyklofosfamid lub ich składniki
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- October 16, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (9)
Kantonsspital Aarau
Aarau, Switzerland
Universitätsspital Basel
Basel, Switzerland
Ente Ospedaliero Cantonale (EOC)-Istituto Oncologico della Svizzera Italiana (IOSI)
Bellinzona, Switzerland
Inselspital Bern - Universitätsklinik für Medizinische Onkologie
Bern, Switzerland
Kantonsspital Graubünden
Chur, Switzerland
Les hôpitaux universitaires de Genève
Geneva, Switzerland
Luzerner Kantonsspital
Lucerne, Switzerland
HOCH Health Ostschweiz - Kantonsspital St. Gallen
Sankt Gallen, Switzerland
Klinik für Hämatologie und Onkologie Hirslanden Zürich
Zurich, Switzerland
Trial contact
Lenka Vokálová, PhD
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 10/14/2026.
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