TLR9 Immunotherapy for Peritoneal Carcinomatosis
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
The goal of this clinical trial is to determine the safety and efficacy of of ACM-CpG for inoperable peritoneal metastases or malignant ascites. The main questions it aims to answer are: • To determine the safety and maximum tolerated dose (MTD) or optimal biologic dose (OBD) of intraperitoneal injection(s) of ACM-CpG for inoperable peritoneal metastases or malignant ascites? Researchers will assign treatment levels using escalating doses of ACM-CpG Therapy. Participants will: * Will receive at least one dose of ACM-CpG therapy on Day 1 of a 28-day treatment cycle. * May receive up to 2 additional injections if they have clinically stable or responsive disease. * Must visit the clinic on Days 1, 4, 7, 10, 14, 21, and 28 for checkups and tests. * Will have a CT scan or MRI performed every 8 weeks for 3 scans and then continue to receive scans every 12 weeks to monitor their disease.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Wiek co najmniej 18 lat
- •Możliwość wyrażenia pisemnej zgody na udział w badaniu
- •Potwierdzony rak jelita grubego lub wyrostka robaczkowego z przerzutami do otrzewnej lub płyn złośliwy w brzuchu
- •Chorobę da się ocenić badaniami lub obrazami
- •Oczekiwana długość życia co najmniej 12 tygodni
- •Ogólny stan zdrowia pozwalający na uczestnictwo w badaniu
- •Wyniki badań krwi w normie (nerki, wątroba, liczba białych i czerwonych krwinek)
- •Gotowość do stosowania antykoncepcji przez czas badania i 6 miesięcy po jego końcu
✗ Disqualifies
- •Wcześniejsze leczenie terapią TLR9
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- October 1, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (1)
Rhode Island and the Miriam Hospitals (Brown University Health)
Providence, United States
Trial contact
Roxanne Wood
Eligibility Screening
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 8/28/2026.
You can help another person
We fund the Radar, this site, and the development of our Grosz dla Życia fundraising platform from donations and our own resources. Every contribution, even a small one, really helps.