Trop2-Targeted NIR-II Fluorescent Probe for Identifying Bladder Cancer in Ex Vivo Bladder Samples
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
Up to 30% of non-muscle-invasive bladder cancer (NMIBC) lesions may be missed by standard white-light cystoscopy, resulting in high tumor recurrence rate. This is a single-center, single-arm, phase 2 prospective study. We apply Trop2-targeted NIR-II fluorescent probe TTP-ICG with rapid incubation to ex vivo bladder specimens from patients undergoing radical cystectomy. Near-infrared fluorescence imaging is performed after short-time incubation and washing. Using histopathology as gold standard, we evaluate the sensitivity, specificity of this imaging system for identifying bladder cancer lesions, and analyze correlation between fluorescence intensity and pathological diagnosis. 30 subjects will be enrolled.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Pacjenci z podejrzeniem lub potwierdzonym rakiem pęcherza, u których planowany jest zabieg usunięcia pęcherza.
- •Osoby zdolne do świadomego wyrażenia zgody na udział w badaniu i przestrzegania jego zasad.
✗ Disqualifies
- •Osoby chore na inne, zaawansowane nowotwory.
- •Osoby z ciężkimi chorobami współistniejącymi, takimi jak wady wrodzone, ostre stany zapalne, znaczne wyniszczenie organizmu, zawał serca lub udar w ciągu ostatnich 6 miesięcy, ciężkie problemy z wątrobą lub nerkami.
- •Kobiety w ciąży lub karmiące piersią.
- •Osoby, które brały udział w innym badaniu klinicznym w ciągu ostatnich 30 dni.
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Maximum age
- 80 Years
- Last updated (source)
- September 30, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (1)
Yunnan Cancer Hospital
Kunming, China
Trial contact
Shengjie Lin, Doctor of Medicine
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 10/1/2026.
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