A Feasibility Study Evaluating a Role for Maintenance Therapy in Patients With Biochemically Progressive Castration Sensitive Prostate Cancer on Intermittent Androgen Deprivation Therapy
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
The goal of this clinical trial is to assess the feasibility of adding a combination of metformin and turmeric as part of a nutritional intervention regimen to the current standard of care, namely, intermittent Androgen Deprivation Therapy (iADT), for patients with castration sensitive biochemical progressive prostate cancer. The main objectives are: * Assess the feasibility of the study population and enrollment. * Evaluate time to PSA relapse with nutritional intervention on iADT. Participants who are receiving iADT will be dispensed Metformin and turmeric and complete a pill diary. Participants will also have blood and stool samples collected and complete quality of life questionnaires. The long-term goal is to further assess the efficacy and safety of this nutritional regimen and the roles of metabolic syndrome, microenvironment/microbiome, and genomic vs epigenomic profiles in the care of these patients through a clinical trial.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Wiek 18 lat lub więcej
- •Wcześniejsze usunięcie prostaty lub radioterapia prostaty
- •Podwyższony poziom PSA (markera nowotworu) potwierdzony co najmniej 2 pomiarami w ciągu tygodnia
- •Czas podwojenia PSA poniżej 9 miesięcy
- •Prawidłowy poziom testosteronu powyżej 150 ng/dl
- •Wcześniejsza hormonalna terapia (nawet przez 2 lata) jest dopuszczalna, jeśli zakończyła się co najmniej rok temu
- •Dobrze ogólny stan zdrowia (zdolny do codziennych czynności)
- •Gotowość do przyjmowania badanych substancji ze wskazanych dawek
✗ Disqualifies
- •Jednoczesne leczenie innego nowotworu (poza rakiem skóry nie wymagającym leczenia)
- •Choroby wątroby lub nerek
- •Zakażenie HIV, wirusem zapalenia wątroby typu B lub C
- •Uczulenie na kurkumę, metforminę lub podobne substancje
- •Historia kwasicy mleczanowej lub ryzyko jej wystąpienia
- •Poważne problemy z sercem, płucami lub nadmierny alkohol
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Maximum age
- 100 Years
- Last updated (source)
- October 15, 2026
- Sex
- Male only
Therapies / drugs in trial
Locations (1)
University of Arkansas for Medical Sciences
Little Rock, United States
Trial contact
Emily Baker
Aaron Holley
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 10/16/2026.
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