The purpose of this study is to compare the efficacy of zipalertinib versus placebo in participants with early stage resected non-small cell lung cancer (NSCLC) harboring uncommon epidermal growth factor receptor mutation (EGFRmt).
A Phase III Study of KN026 in Combination With HB1801 ± Carboplatin as Neoadjuvant Treatment for Early or Locally Advanced HER2-Positive Breast Cancer
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
This trial is no longer recruiting — here are similar active trials
Matched by cancer type/biomarker, currently recruiting.
This is a Phase Ⅲ, randomized, open-label, Sponsor-blinded, 3-arm, global, multicenter study assessing the efficacy and safety of rilvegostomig in combination with fluoropyrimidine and T-DXd (Arm A) compared to trastuzumab, chemotherapy, and pembrolizumab (Arm B) in HER2-positive locally advanced or metastatic gastric or GEJ adenocarcinoma participants whose tumors express PD L1 CPS ≥ 1. Rilvegostomig in combination with trastuzumab and chemotherapy will be evaluated in a separate arm (Arm C) to assess the contribution of each component in the experimental arm.
The overall aim of this project is to help improve the Health Related Quality of Life (HRQOL) of metastatic breast cancer (MBC) patients. There is currently an urgent and unmet need for specific tools to aid in the evaluation of HRQOL in MBC and this project aims to address these needs by developing a comprehensive EORTC questionnaire for assessing the HRQOL of this group. The new module will be used in conjunction with EORTC QLQ-C30 and will provide better measurement of the quality of life issues experienced by women with MBC. Interviews will be conducted with patients from several centres across Europe, guiding the development process in a patient centred way.
This is a Phase III, multicenter, randomized, open-label, global study designed to evaluate the efficacy and safety of inavolisib plus fulvestrant compared with alpelisib plus fulvestrant in patients with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2) -negative, PIK3CA-mutated, locally advanced (LA) or metastatic breast cancer (mBC), who progressed during or after cyclin dependent kinase 4/6i (CDK4/6i)-based therapy. Enrollment for the main study is now complete.
About the trial
This randomized, controlled, open-label, multicenter study will evaluate the safety and efficacy of KN026 in combination with HB1801 ± Carboplatin as neoadjuvant therapy in patients with early or locally advanced HER2-positive breast cancer.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Dobrowolny udział w badaniu i podpisanie świadomej zgody
- •Wiek co najmniej 18 lat
- •Potwierdzony histologicznie i cytologicznie pierwotny nowotwór piersi na wczesnym lub zaawansowanym stadium
- •Ogólny stan zdrowia oceniony na 0-1 (ECOG)
- •Dodatni wynik badania na białko HER2
- •Zgoda na operacyjne leczenie raka piersi po chemioterapii przedoperacyjnej
- •Prawidłowa funkcja organów i szpiku kostnego
- •Zgoda na stosowanie skutecznej antykoncepcji przez co najmniej 3-7 miesięcy po końcu leczenia
✗ Disqualifies
- •Zmiany zapalne lub dwustronne w piersiach
- •Historia innego nowotworu w ciągu ostatnich 3 lat przed badaniem
- •Przeciwwskazania do operacji piersi
- •Wcześniejsza operacja lub biopsja piersi przed włączeniem do badania
- •Poprzednia chemioterapia, hormonoterapia lub biologiczne leczenie raka piersi
- •Uczulenie na leki stosowane w badaniu
- •Alergia na kortykosteroidy lub przeciwwskazania do ich stosowania
- •Wrodzona lub nabyta niedoborność odporności, w tym HIV
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- July 7, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (1)
Clinical Trials Information Group
Shanghai, China
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/1/2026.
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