This study is open to adults with extensive-stage small cell lung cancer. The purpose of this study is to find out how well people with this type of cancer tolerate taking study medicines called obrixtamig and pumitamig. Another purpose is to check whether the combination study treatment can make tumours shrink. Obrixtamig and pumitamig are being developed to help the immune system fight cancer. Participants are put into 2 groups. One group gets obrixtamig and pumitamig. The other group gets obrixtamig and pumitamig with standard chemotherapy (carboplatin and etoposide). All study treatments are given as infusions into a vein. This study does not have a fixed duration. Participants can receive obrixtamig and pumitamig for up to 2 years if they benefit from treatment and can tolerate it. Participants visit the study site regularly, with some overnight stays required. During this time, doctors regularly check for health problems that could be caused by the study treatment. They also monitor the size of the tumour(s) and take laboratory tests.
A Study to Compare the Efficacy and Safety of BMS-986365 Versus the Investigator's Choice of Therapy in Participants With Metastatic Castration-resistant Prostate Cancer
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
This trial is no longer recruiting — here are similar active trials
Matched by cancer type/biomarker, currently recruiting.
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The goal of this randomized, double-blind, multi-regional phase 3 study of cadonilimab combined with chemotherapy versus chemotherapy in combination with or without nivolumab for the first-line treatment of participants with HER2-negative, previously untreated, unresectable or metastatic gastric or gastroesophageal junction adenocarcinoma trial is to compare OS between cadonilimab combined with chemotherapy and chemotherapy in combination with or without nivolumab in the ITT population.
About the trial
The purpose of this study is to compare the efficacy and safety of BMS-986365 versus the investigator's choice of therapy in participants with Metastatic Castration-resistant Prostate Cancer.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Potwierdzony rozpoznanie raka gruczołowego prostaty
- •Widoczne przerzuty raka w kościach lub innych organach (potwierdzone badaniami)
- •Brak objawów lub łagodne objawy z bólem poniżej 4 punktów w skali oceny bólu
- •Wcześniejsze leczenie lekami hamującymi receptory androgenowe (np. abiraterone, enzalutamide)
✗ Disqualifies
- •Poważne problemy z pracą serca lub istotna choroba serca
- •Przerzuty raka w mózgu
- •Przerzuty raka w wątrobie
- •Superscan w badaniu kości (rozpowszechnione zajęcie szkieletu)
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- September 30, 2026
- Sex
- Male only
Therapies / drugs in trial
Locations (227)
Local Institution - 0330
Birmingham, United States
Local Institution - 0329
Gilbert, United States
Local Institution - 0370
Anaheim, United States
Local Institution - 0015
La Jolla, United States
Local Institution - 0224
Los Alamitos, United States
Local Institution - 0016
San Francisco, United States
Local Institution - 0411
San Francisco, United States
Local Institution - 0238
Aurora, United States
Local Institution - 0294
Denver, United States
Local Institution - 0419
Lakewood, United States
Local Institution - 0413
Washington D.C., United States
Local Institution - 0426
Lakeland, United States
Local Institution - 0077
Athens, United States
Local Institution - 0048
Chicago, United States
Local Institution - 0331
Westwood, United States
Local Institution - 0060
Wichita, United States
Local Institution - 0054
Baltimore, United States
Local Institution - 0019
Baltimore, United States
Local Institution - 0344
Frederick, United States
Local Institution - 0429
Sewell, United States
Local Institution - 0081
Albuquerque, United States
Local Institution - 0334
Albuquerque, United States
Local Institution - 0197
Buffalo, United States
Local Institution - 0412
Mineola, United States
Local Institution - 0069
New York, United States
Local Institution - 0076
New York, United States
Local Institution - 0085
New York, United States
Local Institution - 0071
New York, United States
Local Institution - 0225
Syracuse, United States
Local Institution - 0056
Columbus, United States
Local Institution - 0067
Portland, United States
Local Institution - 0416
Portland, United States
Local Institution - 0345
Philadelphia, United States
Local Institution - 0414
Philadelphia, United States
Local Institution - 0057
Philadelphia, United States
Local Institution - 0349
Willow Grove, United States
Local Institution - 0055
Charleston, United States
Local Institution - 0079
Myrtle Beach, United States
Local Institution - 0335
Nashville, United States
Local Institution - 0018
Austin, United States
Local Institution - 0114
Austin, United States
Local Institution - 0042
Houston, United States
Local Institution - 0220
Houston, United States
Local Institution - 0109
Murray, United States
Local Institution - 0050
Charlottesville, United States
Local Institution - 0078
Seattle, United States
Local Institution - 0293
Vancouver, United States
Local Institution - 0112
Milwaukee, United States
Local Institution - 0125
CABA, Argentina
Local Institution - 0124
Ciudad Autónoma de Buenos Aires, Argentina
Local Institution - 0128
ABB, Argentina
Local Institution - 0235
Córdoba, Argentina
Local Institution - 0130
Río Cuarto, Argentina
Local Institution - 0136
Viedma, Argentina
Local Institution - 0129
Buenos Aires, Argentina
Local Institution - 0430
Córdoba, Argentina
Local Institution - 0366
Campbelltown, Australia
Local Institution - 0359
Darlinghurst, Australia
Local Institution - 0356
Macquarie University, Australia
Local Institution - 0360
Port Macquarie, Australia
Local Institution - 0355
Wahroonga, Australia
Local Institution - 0347
Greenslopes, Australia
Local Institution - 0351
Southport, Australia
Local Institution - 0362
Adelaide, Australia
Local Institution - 0358
Elizabeth Vale, Australia
Local Institution - 0352
Kurralta Park, Australia
Local Institution - 0354
Hobart, Australia
Local Institution - 0363
Heidelberg, Australia
Local Institution - 0353
Malvern, Australia
Local Institution - 0348
Melbourne, Australia
Local Institution - 0361
Melbourne, Australia
Local Institution - 0357
Murdoch, Australia
Local Institution - 0369
Krems, Austria
Local Institution - 0373
Linz, Austria
Local Institution - 0367
Salzburg, Austria
Local Institution - 0368
Vienna, Austria
Local Institution - 0025
Belo Horizonte, Brazil
Local Institution - 0035
Natal, Brazil
Local Institution - 0026
Porto Alegre, Brazil
Local Institution - 0395
São Paulo, Brazil
Local Institution - 0031
São Paulo, Brazil
Local Institution - 0304
Kelowna, Canada
Local Institution - 0152
Vancouver, Canada
Local Institution - 0151
Halifax, Canada
Local Institution - 0193
Toronto, Canada
Local Institution - 0093
Chicoutimi, Canada
Local Institution - 0149
Montreal, Canada
Local Institution - 0305
Montreal, Canada
Local Institution - 0150
Québec, Canada
Local Institution - 0164
Rimouski, Canada
Local Institution - 0236
Valdivia, Chile
Local Institution - 0135
Santiago, Chile
Local Institution - 0132
Santiago, Chile
Local Institution - 0127
Viña del Mar, Chile
Local Institution - 0232
Hefei, China
Local Institution - 0192
Beijing, China
Local Institution - 0249
Fuzhou, China
Local Institution - 0213
Xiamen, China
Local Institution - 0226
Guangzhou, China
Local Institution - 0180
Guangzhou, China
Local Institution - 0415
Huizhou, China
Local Institution - 0417
Changzhou, China
Local Institution - 0233
Nanjing, China
Local Institution - 0229
Nanjing, China
Local Institution - 0219
Nanchang, China
Local Institution - 0191
Jinan, China
Local Institution - 0221
Yantai, China
Local Institution - 0214
Shanghai, China
Local Institution - 0240
Chengdu, China
Local Institution - 0278
Chengdu, China
Local Institution - 0283
Chengdu, China
Local Institution - 0218
Ürümqi, China
Local Institution - 0196
Hangzhou, China
Local Institution - 0281
Linhai, China
Local Institution - 0008
Brno, Czechia
Local Institution - 0005
Hradec Králové, Czechia
Local Institution - 0010
Olomouc, Czechia
Local Institution - 0009
Prague, Czechia
Local Institution - 0004
Prague, Czechia
Local Institution - 0006
Prague, Czechia
Local Institution - 0243
Copenhagen, Denmark
Local Institution - 0098
Copenhagen, Denmark
Local Institution - 0396
Aarhus, Denmark
Local Institution - 0100
Aalborg, Denmark
Local Institution - 0096
Kuopio, Finland
Local Institution - 0285
Tampere, Finland
Local Institution - 0242
Turku, Finland
Local Institution - 0101
Oulu, Finland
Local Institution - 0167
Nice, France
Local Institution - 0432
Dijon, France
Local Institution - 0307
Toulouse, France
Local Institution - 0177
Vandœuvre-lès-Nancy, France
Local Institution - 0166
Pierre-Bénite, France
Local Institution - 0231
Le Mans, France
Local Institution - 0179
Villejuif, France
Local Institution - 0165
Clermont-Ferrand, France
Local Institution - 0169
Strasbourg, France
Local Institution - 0421
Nürtingen, Germany
Local Institution - 0374
München, Germany
Local Institution - 0371
Lübeck, Germany
Local Institution - 0380
Jena, Germany
Local Institution - 0382
Bonn, Germany
Local Institution - 0375
Essen, Germany
Local Institution - 0378
Hamburg, Germany
Local Institution - 0379
Heidelberg, Germany
Local Institution - 0377
Herne, Germany
Local Institution - 0376
Tübingen, Germany
Local Institution - 0372
Würzburg, Germany
Local Institution - 0271
Cork, Ireland
Local Institution - 0272
Dublin, Ireland
Local Institution - 0273
Dublin, Ireland
Local Institution - 0206
Kfar Saba, Israel
Local Institution - 0208
Petah Tikva, Israel
Local Institution - 0207
Ramat Gan, Israel
Local Institution - 0210
Ẕerifin, Israel
Local Institution - 0209
Haifa, Israel
Local Institution - 0157
Milan, Italy
Local Institution - 0234
Orbassano, Italy
Local Institution - 0155
Rome, Italy
Local Institution - 0153
Padova, Italy
Local Institution - 0156
Arezzo, Italy
Local Institution - 0409
Foggia, Italy
Local Institution - 0160
Naples, Italy
Local Institution - 0159
Terni, Italy
Local Institution - 0158
Trento, Italy
Local Institution - 0121
Mexico City, Mexico
Local Institution - 0120
Guadalajara, Mexico
Local Institution - 0001
Guadalajara, Mexico
Local Institution - 0002
Monterrey, Mexico
Local Institution - 0122
Chihuahua City, Mexico
Local Institution - 0119
Puebla City, Mexico
Local Institution - 0365
Poznan, Poland
Local Institution - 0346
Wroclaw, Poland
Local Institution - 0187
Warsaw, Poland
Local Institution - 0190
Opole, Poland
Local Institution - 0186
Gdansk, Poland
Local Institution - 0185
Bytom, Poland
Local Institution - 0189
Bydgoszcz, Poland
Local Institution - 0336
Katowice, Poland
Local Institution - 0117
Yauco, Puerto Rico
Local Institution - 0139
Craiova, Romania
Local Institution - 0144
Cluj-Napoca, Romania
Local Institution - 0145
Cluj-Napoca, Romania
Local Institution - 0141
Iași, Romania
Local Institution - 0142
Ploieşti, Romania
Local Institution - 0381
Prešov, Slovakia
Local Institution - 0389
Goyang-si, South Korea
Local Institution - 0386
Seongnam, South Korea
Local Institution - 0385
Seoul, South Korea
Local Institution - 0387
Seoul, South Korea
Local Institution - 0388
Seoul, South Korea
Local Institution - 0384
Seoul, South Korea
Local Institution - 0312
Córdoba, Spain
Local Institution - 0310
Barcelona, Spain
Local Institution - 0311
Sabadell, Spain
Local Institution - 0325
Barakaldo, Spain
Local Institution - 0314
Santander, Spain
Local Institution - 0315
Barcelona, Spain
Local Institution - 0319
Lugo, Spain
Local Institution - 0321
Madrid, Spain
Local Institution - 0316
Madrid, Spain
Local Institution - 0317
Madrid, Spain
Local Institution - 0323
Madrid, Spain
Local Institution - 0326
Majadahonda, Spain
Local Institution - 0406
Pamplona, Spain
Local Institution - 0407
Ourense, Spain
Local Institution - 0320
Badajoz, Spain
Local Institution - 0328
Burgos, Spain
Local Institution - 0318
Granada, Spain
Local Institution - 0309
Madrid, Spain
Local Institution - 0327
Málaga, Spain
Local Institution - 0322
Seville, Spain
Local Institution - 0313
Seville, Spain
Local Institution - 0324
Valencia, Spain
Local Institution - 0099
Lund, Sweden
Local Institution - 0408
Solna, Sweden
Local Institution - 0097
Uppsala, Sweden
Local Institution - 0095
Gothenburg, Sweden
Local Institution - 0398
Taichung, Taiwan
Local Institution - 0399
Taipei, Taiwan
Local Institution - 0397
Taipei, Taiwan
Local Institution - 0420
Taoyuan, Taiwan
Local Institution - 0393
Glasgow, United Kingdom
Local Institution - 0383
Northwood, United Kingdom
Local Institution - 0266
London, United Kingdom
Local Institution - 0391
London, United Kingdom
Local Institution - 0248
Manchester, United Kingdom
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/23/2026.
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