Saruparib in Combination With Physician's Choice of ARPI in Patients With mHSPC Previously Treated With Docetaxel or 177Lu-PSMA Therapy Without Disease Progression and PSA ≥ 0.2 ng/mL (EvoPAR-PR05)
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
The primary objective of this study is to measure efficacy of saruparib + physician's choice of ARPI compared with placebo + ARPI in men with metastatic hormone-sensitive prostate cancer (mHSPC) who have previously received docetaxel chemotherapy or a prostate-specific membrane antigen (PSMA)-directed lutetium-177 radioligand therapy with no evidence of disease progression and PSA ≥ 0.2 ng/mL.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Wiek co najmniej 18 lat w chwili podpisania zgody na udział w badaniu
- •Potwierdzony histologicznie rak gruczołowy prostaty, pierwotny lub nawracający, wrażliwy na hormony
- •Przerzuty raka potwierdzone przed poprzednim leczeniem chemioterapią lub radioterapią izotopową
- •Wcześniejsze leczenie chemioterapią lub radioterapią izotopową zakończone w ciągu ostatnich 6 miesięcy
- •Obecne leczenie hormonalne oraz brak oznak postępu choroby
- •Poziom PSA co najmniej 0,2 ng/mL w ciągu 14 dni przed włączeniem do badania
- •Odpowiednia funkcja narządów wewnętrznych i szpiku kostnego
- •Oczekiwana długość życia co najmniej 6 miesięcy
✗ Disqualifies
- •Alergia na saruparib, leki hormonalne lub składniki tych leków
- •Historia poważnych zaburzeń morfologii krwi (zbyt mało białych krwinek lub płytek krwi)
- •Склонność do krwawień, aktywny wrzód żołądka lub niedawny udar krwotoczny
- •Kontrainformacje do otrzymania leków badanych ze względu na inne choroby
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- October 15, 2026
- Sex
- Male only
Therapies / drugs in trial
Locations (210)
Research Site
Hot Springs, United States
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Springdale, United States
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Beverly Hills, United States
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Los Alamitos, United States
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Los Angeles, United States
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San Diego, United States
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Margate, United States
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Miami, United States
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Orlando, United States
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Honolulu, United States
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Chicago, United States
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Chicago, United States
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Elk Grove Village, United States
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Hinsdale, United States
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Ames, United States
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Baltimore, United States
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Baltimore, United States
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Towson, United States
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Detroit, United States
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Grand Rapids, United States
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Marshall, United States
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Camden, United States
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Albuquerque, United States
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Shirley, United States
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Canton, United States
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Cincinnati, United States
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Portland, United States
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Portland, United States
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Greenville, United States
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Aberdeen, United States
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Mitchell, United States
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Pierre, United States
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Sioux Falls, United States
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Yankton, United States
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Nashville, United States
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Austin, United States
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Dallas, United States
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Fort Worth, United States
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Longview, United States
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Wichita Falls, United States
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Salt Lake City, United States
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Spokane, United States
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Graz, Austria
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Linz, Austria
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Salzburg, Austria
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Vienna, Austria
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Barretos, Brazil
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Brasília, Brazil
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Natal, Brazil
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Porto Alegre, Brazil
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São Caetano do Sul, Brazil
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São Paulo, Brazil
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São Paulo, Brazil
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Calgary, Canada
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Edmonton, Canada
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Abbotsford British Columbia, Canada
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Brampton, Canada
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Kitchener, Canada
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North York, Canada
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Ottawa, Canada
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Toronto, Canada
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Windsor, Canada
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Greenfield Park, Canada
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Montreal, Canada
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Montreal, Canada
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Saint-Jérôme, Canada
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Saskatoon, Canada
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Beijing, China
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Changsha, China
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Chengdu, China
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Chengdu, China
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Chongqing, China
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Fuzhou, China
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Guangzhou, China
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Guangzhou, China
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Guiyang, China
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Jiaxing, China
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Jinan, China
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Kunming, China
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Kunming, China
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Lanzhou, China
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Nanchang, China
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Nanjing, China
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Nantong, China
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Ningbo, China
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Qingdao, China
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Shandong, China
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Shanghai, China
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Shanghai, China
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Wenzhou, China
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Wuhan, China
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Wuhan, China
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Wuhan, China
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Xi'an, China
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Angers, France
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Caen, France
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Montpellier, France
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Paris, France
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Poitiers, France
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Bergisch Gladbach, Germany
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Berlin, Germany
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Berlin, Germany
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Bonn, Germany
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Cologne, Germany
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Dresden, Germany
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Duisburg, Germany
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Essen, Germany
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Frankfurt am Main, Germany
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Göttingen, Germany
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Hamburg, Germany
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Heidelberg, Germany
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Herne, Germany
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Mannheim, Germany
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Marburg, Germany
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Mettmann, Germany
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München, Germany
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Münster, Germany
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Nuremberg, Germany
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Nürtingen, Germany
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Rostock, Germany
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Stuttgart, Germany
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Ulm, Germany
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Würzburg, Germany
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Hong Kong, Hong Kong
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Hong Kong, Hong Kong
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Budapest, Hungary
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Budapest, Hungary
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Budapest, Hungary
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Pécs, Hungary
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Szeged, Hungary
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Ansārinagar, India
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Bangalore, India
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Delhi, India
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Kannur, India
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Nagpur, India
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New Delhi, India
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Vadodara, India
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Bari, Italy
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Genova, Italy
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Padova, Italy
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Rozzano, Italy
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Chiba, Japan
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Fukuoka, Japan
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Fukuoka, Japan
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Hiroshima, Japan
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Kamakura-shi, Japan
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Kawagoe-shi, Japan
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Kisarazu-shi, Japan
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Kita-gun, Japan
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Kobe, Japan
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Kumamoto, Japan
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Maebashi, Japan
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Nagano, Japan
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Nagasaki, Japan
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Nagoya, Japan
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Nagoya, Japan
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Osaka, Japan
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Sakai, Japan
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Sakura-shi, Japan
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Sapporo, Japan
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Suita-shi, Japan
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Yokohama, Japan
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Gdansk, Poland
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Koszalin, Poland
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Krakow, Poland
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Lodz, Poland
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Olsztyn, Poland
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Poznan, Poland
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Warsaw, Poland
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Wroclaw, Poland
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Rio Piedras, Puerto Rico
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Daegu, South Korea
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Goyang-si, South Korea
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Seoul, South Korea
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Seoul, South Korea
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Seoul, South Korea
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Seoul, South Korea
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Barcelona, Spain
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Barcelona, Spain
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Córdoba, Spain
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Las Palmas de Gran Canaria, Spain
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Madrid, Spain
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Madrid, Spain
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Santander, Spain
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Valencia, Spain
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Aarau, Switzerland
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Chur, Switzerland
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Kaohsiung City, Taiwan
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Taichung, Taiwan
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Tainan, Taiwan
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Taipei, Taiwan
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Taipei, Taiwan
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Taoyuan, Taiwan
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Bangkok, Thailand
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Bangkok, Thailand
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Bangkok, Thailand
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Khlong Luang, Thailand
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Songkhla, Thailand
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Adana, Turkey (Türkiye)
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Ankara, Turkey (Türkiye)
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Ankara, Turkey (Türkiye)
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Cordaleo, Turkey (Türkiye)
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Istanbul, Turkey (Türkiye)
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Izmir, Turkey (Türkiye)
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Cambridge, United Kingdom
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Glasgow, United Kingdom
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London, United Kingdom
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London, United Kingdom
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Manchester, United Kingdom
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Plymouth, United Kingdom
Trial contact
AstraZeneca Clinical Study Information Center
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 10/16/2026.
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