Inositol and Metformin Administration in Mediterranean Diet and Low-Carbohydrate Diets in Women With PCOS
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
Polycystic ovary syndrome (PCOS) is a common endocrine disorder frequently associated with obesity, insulin resistance (IR), and metabolic dysfunction. Although lifestyle modification is recommended as first-line therapy, the optimal dietary approach for women with PCOS remains uncertain. This randomized, controlled, open-label, parallel-group trial aims to compare the effects of a Mediterranean diet (MD) and a low-carbohydrate diet (LCD), each combined with metformin, inositol, or folic acid (active control), in obese women with PCOS and IR. A total of 102 participants will be randomly assigned to one of six intervention groups and followed for two months. Anthropometric measurements, body composition, biochemical parameters, and hedonic hunger will be assessed at baseline and after the intervention. The primary outcome is the change in insulin resistance, assessed by the Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), from baseline to 2 months. Secondary outcomes include changes in body composition, metabolic and biochemical parameters, and hedonic hunger.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Wiek 20-40 lat
- •Zdiagnozowany zespół policystycznych jajników (PCOS)
- •Zaburzenia insuliny (rozpoznane niedawno lub w ciągu ostatnich 3 miesięcy)
- •Otyłość - wskaźnik masy ciała (BMI) między 30 a 40 kg/m²
✗ Disqualifies
- •Ciąża lub karmienie piersią
- •Planowanie lub wykonywanie zabiegu in vitro (IVF)
- •Zdiagnozowana wczesna menopauza
- •Cukrzyca lub przyjmowanie leków przeciwcukrzycowych
- •Przewlekłe choroby (wątroba, nerki, nowotwory)
- •Choroby psychiatryczne
- •Przyjmowanie regularnych leków
- •Palenie papierosów, picie alkoholu
Simplified criteria — AI translation
Trial details
- Minimum age
- 20 Years
- Maximum age
- 40 Years
- Last updated (source)
- October 16, 2026
- Sex
- Female only
Therapies / drugs in trial
Locations (1)
Dicle University Hospital
Diyarbakır, Turkey (Türkiye)
Trial contact
Esra Ucar, MSc
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 10/17/2026.
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