The purpose of this study is to compare the efficacy of zipalertinib versus placebo in participants with early stage resected non-small cell lung cancer (NSCLC) harboring uncommon epidermal growth factor receptor mutation (EGFRmt).
A Study of the Efficacy and Safety of Camrelizumab Plus Radiotherapy for Patients With Early Triple-Negative Breast
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
This trial is no longer recruiting — here are similar active trials
Matched by cancer type/biomarker, currently recruiting.
The overall aim of this project is to help improve the Health Related Quality of Life (HRQOL) of metastatic breast cancer (MBC) patients. There is currently an urgent and unmet need for specific tools to aid in the evaluation of HRQOL in MBC and this project aims to address these needs by developing a comprehensive EORTC questionnaire for assessing the HRQOL of this group. The new module will be used in conjunction with EORTC QLQ-C30 and will provide better measurement of the quality of life issues experienced by women with MBC. Interviews will be conducted with patients from several centres across Europe, guiding the development process in a patient centred way.
This is a Phase III, multicenter, randomized, open-label, global study designed to evaluate the efficacy and safety of inavolisib plus fulvestrant compared with alpelisib plus fulvestrant in patients with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2) -negative, PIK3CA-mutated, locally advanced (LA) or metastatic breast cancer (mBC), who progressed during or after cyclin dependent kinase 4/6i (CDK4/6i)-based therapy. Enrollment for the main study is now complete.
The main purpose of this study is to evaluate the efficacy of divarasib compared with investigator's choice of immunotherapy (pembrolizumab or nivolumab) or observation in participants with resected Kirsten rat sarcoma viral oncogene homolog glycine 12 to cysteine (KRAS G12C)-positive Stage II-IIIB NSCLC, regardless of tumor programmed death-ligand 1 (PD-L1) status, who have not achieved pathologic complete response (pCR) following neoadjuvant chemoimmunotherapy.
About the trial
This is a open-labeled, single-arm, Investigator-initiated clinical trial of camrelizumab (an anti-PD-1 antibody) in combination with radiotherapy in patients with early triple-negative breast cancer. We will enroll 60 subjects. This study aims to evaluate the efficacy and safety of camrelizumab combined with radiotherapy in the treatment of early TNBC。
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Kobieta w wieku od 18 do 75 lat
- •Potwierdzony nowotwór piersi typu TNBC (negatywny na receptory hormonalne i HER2)
- •Badanie genetyczne mające na celu określenie podtypu nowotworu i poziomu markerów immunologicznych
- •Planowana operacja piersi z całkowitym lub częściowym usunięciem piersi, spełniająca określone kryteria wielkości guza i przerzutów węzłowych
- •Prawidłowe wyniki badań krwi i funkcji nerek: liczba neutrofili ≥1500/uL, płytki ≥100 000/uL, hemoglobina ≥9,0g/dL
- •Prawidłowy elektrokardiogram serca (QTcF <470 ms)
- •Ujemny test ciążowy (dla kobiet mogących zajść w ciążę) i zgoda na antykoncepcję przez czas badania i 90 dni po nim
- •Podpisana świadoma zgoda na udział w badaniu i zdolność do jego wykonania
✗ Disqualifies
- •Inny aktywny nowotwór wymagający leczenia (z wyjątkiem raka skóry lub raka in situ poddanego kuracyjnemu leczeniu)
- •Przerzuty nowotworu do odległych narządów w momencie diagnozy
- •Poprzednia terapia lekami anty-PD-1 lub anty-PD-L1 albo ciężka alergia na przeciwciała monoklonalne
- •Aktywna choroba autoimmunologiczna lub historia choroby autoimmunologicznej (takie jak zapalenie wątroby, zapalenie płuc, zapalenie oczu)
- •Choroba autoimmunologiczna wymagająca systemowego leczenia w ciągu ostatnich 2 lat (lekami immunosupresyjnymi lub kortykosteroidami)
- •Płyn w jamie brzusznej (ascites)
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Maximum age
- 75 Years
- Last updated (source)
- July 22, 2020
- Sex
- Female only
Therapies / drugs in trial
Locations (1)
Chunling Jiang
Nanchang, China
Trial contact
Chunling Jiang
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/1/2026.
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