Testing the Addition of Lenalidomide and Nivolumab to the Usual Treatment for Primary CNS Lymphoma
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This phase I trial tests the safety, side effects, best dose and effectiveness of lenalidomide when added to nivolumab and the usual drugs (rituximab and methotrexate) in patients with primary central nervous system (CNS) lymphoma. Lenalidomide may stop or slow primary CNS lymphoma by blocking the growth of new blood vessels necessary for tumor growth. Immunotherapy with monoclonal antibodies, such as nivolumab, may help the body's immune system attack the cancer, and may interfere with the ability of cancer cells to grow and spread. Rituximab is a monoclonal antibody that may interfere with the ability of cancer cells to grow and spread. Methotrexate is frequently combined with other chemotherapy agents to improve response. This study may help increase the understanding of lenalidomide and nivolumab use in primary CNS lymphoma treatment. In addition, it may help researchers see whether the control of CNS lymphoma can be extended by using these study drugs as maintenance (prolonged therapy) after control is achieved with the initial chemotherapy regimen (induction).
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Potwierdzony histologicznie chłoniak pierwotny rozlany z dużych komórek B w OUN (z biopsji lub płynu mózgowo-rdzeniowego/oka).
- •Brak wcześniejszej chemioterapii lub radioterapii z powodu chłoniaka.
- •Brak wcześniejszego przeszczepu narządów lub komórek macierzystych.
- •Kobiety niebędące w ciąży ani niekarmiące (wymagany test ciążowy).
- •Wiek co najmniej 18 lat.
- •Ogólny stan zdrowia pozwalający na leczenie (Karnofsky > 40).
- •Odpowiednie wyniki badań krwi (białe krwinki, płytki krwi).
- •Prawidłowe wyniki badań nerek i wątroby.
✗ Disqualifies
- •Chłoniak poza ośrodkowym układem nerwowym.
- •Choroby autoimmunologiczne (mogące wpływać na narządy lub wymagać leczenia immunosupresyjnego).
- •Wcześniejsza chemioterapia lub radioterapia w leczeniu chłoniaka.
- •Wcześniejszy przeszczep narządów lub komórek macierzystych.
- •Ciąża lub karmienie piersią.
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- June 30, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (55)
Cedars-Sinai Medical Center
Los Angeles, United States
UCSF Medical Center-Parnassus
San Francisco, United States
UM Sylvester Comprehensive Cancer Center at Coral Gables
Coral Gables, United States
UM Sylvester Comprehensive Cancer Center at Deerfield Beach
Deerfield Beach, United States
University of Miami Miller School of Medicine-Sylvester Cancer Center
Miami, United States
UM Sylvester Comprehensive Cancer Center at Kendall
Miami, United States
University of Miami Sylvester Comprehensive Cancer Center at Sole Mia
North Miami, United States
UM Sylvester Comprehensive Cancer Center at Plantation
Plantation, United States
UI Health Care Mission Cancer and Blood - Ankeny Clinic
Ankeny, United States
Saint Anthony Regional Hospital
Carroll, United States
UI Health Care Mission Cancer and Blood - West Des Moines Clinic
Clive, United States
Iowa Methodist Medical Center
Des Moines, United States
UI Health Care Mission Cancer and Blood - Des Moines Clinic
Des Moines, United States
Broadlawns Medical Center
Des Moines, United States
Mercy Medical Center - Des Moines
Des Moines, United States
UI Health Care Mission Cancer and Blood - Laurel Clinic
Des Moines, United States
Iowa Lutheran Hospital
Des Moines, United States
UI Healthcare Mission Cancer and Blood - Fort Dodge
Fort Dodge, United States
University of Iowa/Holden Comprehensive Cancer Center
Iowa City, United States
UI Health Care Mission Cancer and Blood - Waukee Clinic
Waukee, United States
Methodist West Hospital
West Des Moines, United States
LSU Health Baton Rouge-North Clinic
Baton Rouge, United States
Our Lady of the Lake Physician Group
Baton Rouge, United States
MaineHealth Maine Medical Center - Portland
Portland, United States
MaineHealth Maine Medical Center- Scarborough
Scarborough, United States
MaineHealth Cancer Care and IV Therapy - South Portland
South Portland, United States
Hickman Cancer Center
Adrian, United States
Toledo Clinic Cancer Centers-Monroe
Monroe, United States
Siteman Cancer Center at Saint Peters Hospital
City of Saint Peters, United States
Siteman Cancer Center at West County Hospital
Creve Coeur, United States
Washington University School of Medicine
St Louis, United States
Siteman Cancer Center-South County
St Louis, United States
Siteman Cancer Center at Christian Hospital
St Louis, United States
Overlook Hospital
Summit, United States
Northwell Health/Center for Advanced Medicine
Lake Success, United States
North Shore University Hospital
Manhasset, United States
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
New York, United States
NYP/Weill Cornell Medical Center
New York, United States
State University of New York Upstate Medical University
Syracuse, United States
UNC Lineberger Comprehensive Cancer Center
Chapel Hill, United States
Ohio State University Comprehensive Cancer Center
Columbus, United States
Toledo Clinic Cancer Centers-Toledo
Toledo, United States
University of Oklahoma Health Sciences Center
Oklahoma City, United States
Rhode Island Hospital
Providence, United States
Medical University of South Carolina
Charleston, United States
UT Southwestern/Simmons Cancer Center-Dallas
Dallas, United States
Huntsman Cancer Institute/University of Utah
Salt Lake City, United States
West Virginia University Healthcare
Morgantown, United States
Marshfield Medical Center-EC Cancer Center
Eau Claire, United States
Gundersen Lutheran Medical Center
La Crosse, United States
Marshfield Medical Center-Marshfield
Marshfield, United States
Marshfield Medical Center - Minocqua
Minocqua, United States
Marshfield Medical Center-Rice Lake
Rice Lake, United States
Marshfield Medical Center-River Region at Stevens Point
Stevens Point, United States
Marshfield Medical Center - Weston
Weston, United States
Trial contact
Site Public Contact
Justin M. Darrah
PRINCIPAL_INVESTIGATOR
Site Public Contact
James L. Rubenstein
PRINCIPAL_INVESTIGATOR
Site Public Contact
Alvaro J. Alencar
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Seema Harichand-Herdt
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Site Public Contact
Richard L. Deming
PRINCIPAL_INVESTIGATOR
Site Public Contact
Eric Mou
PRINCIPAL_INVESTIGATOR
Site Public Contact
Christine Lu-Emerson
PRINCIPAL_INVESTIGATOR
Site Public Contact
Neha Mehta-Shah
PRINCIPAL_INVESTIGATOR
Site Public Contact
Samuel Singer
PRINCIPAL_INVESTIGATOR
Site Public Contact
Aya Haggiagi
PRINCIPAL_INVESTIGATOR
Site Public Contact
Christopher E. Dittus
PRINCIPAL_INVESTIGATOR
Site Public Contact
Timothy J. Voorhees
PRINCIPAL_INVESTIGATOR
Site Public Contact
Sami Ibrahimi
PRINCIPAL_INVESTIGATOR
Site Public Contact
Thomas Ollila
PRINCIPAL_INVESTIGATOR
Site Public Contact
Scott M. Lindhorst
PRINCIPAL_INVESTIGATOR
Site Public Contact
Praveen R. Geethakumari
PRINCIPAL_INVESTIGATOR
Site Public Contact
Sonikpreet Aulakh
PRINCIPAL_INVESTIGATOR
Site Public Contact
Kareem H. Abdelhadi
PRINCIPAL_INVESTIGATOR
Site Public Contact
Michael O. Ojelabi
PRINCIPAL_INVESTIGATOR
Contact information from ClinicalTrials.gov. Contact in English.
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/3/2026.