Study Evaluating the Efficacy of KITE-753 Versus Axicabtagene Ciloleucel in Participants With Relapsed or Refractory Large B-Cell Lymphoma After First-Line Therapy
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
The goal of this clinical study is to compare the study drug KITE-753 versus axicabtagene ciloleucel (axi-cel) in adult participants with relapsed or refractory (r/r) large B-cell lymphoma (LBCL) after one prior line of therapy. The primary objective of this study is to evaluate the efficacy of KITE-753 versus axicabtagene ciloleucel.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Diagnoza nawrotowego lub opornego chłoniaka B-komórkowego
- •Wcześniejsze leczenie nie powiodło się (choroba oporna na chemioterapię lub nawrót w ciągu 12 miesięcy)
- •Wcześniejsze leczenie zawierało przeciwciało anty-CD20 i chemioterapię z antracyklinami
- •Co najmniej jeden widoczny guz do zmierzenia
- •Brak dodatkowego leczenia między pierwszą terapią a włączeniem do badania (poza sterydami lub promieniowaniem lokalnym)
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- October 8, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (42)
City of Hope Arizona
Goodyear, United States
City of Hope (City of Hope National Medical Center, City of Hope Medical Center)
Duarte, United States
Stanford University
Stanford, United States
Colorado Blood Cancer Institute
Denver, United States
Yale University School of Medicine
New Haven, United States
Moffitt Cancer Center
Tampa, United States
Southeastern Regional Medical Center, Inc. dba City of Hope Atlanta
Newnan, United States
University of Illinois
Chicago, United States
City of Hope - Chicago
Zion, United States
University of Maryland St. Joseph Medical Center
Baltimore, United States
Washington University
St Louis, United States
Weill Cornell Medicine-NewYork-Presbyterian Hospital
New York, United States
Memorial Sloan Kettering Cancer Center
New York, United States
Montefiore Medical Center
The Bronx, United States
Novant Health Cancer Institute - Hematology
Charlotte, United States
Henry-Joyce Cancer Clinic
Nashville, United States
Tennessee Oncology, PLLC - Investigational Drug Services
Nashville, United States
St. David's South Austin Medical Center
Austin, United States
Inova Shar Cancer Institute
Fairfax, United States
Fred Hutchinson Cancer Center
Seattle, United States
West Virginia University
Morgantown, United States
Royal Prince Alfred Hospital
Camperdown, Australia
Concord Repatriation General Hospital
Sydney, Australia
Epworth Healthcare
East Melbourne, Australia
Universitair Ziekenhuis Antwerpen
Edegem, Belgium
Universitair Ziekenhuis Gent
Ghent, Belgium
Jewish General Hospital
Montreal, Canada
McGill University Health Centre
Montreal, Canada
CHU de Québec, Hôpital de l'Enfant-Jésus
Québec, Canada
Hopital Saint Eloi
Montpellier, France
Universitatsklinikum Wurzburg
Würzburg, Germany
National Cancer Center Hospital
Tokyo, Japan
Toranomon Hospital
Tokyo, Japan
Hospital Clinic de Barcelona
Barcelona, Spain
Institut Catala d'Oncologia
Barcelona, Spain
Hospital General Universitario Gregorio Maranon
Madrid, Spain
Hospital Universitario 12 de Octubre
Madrid, Spain
Clinica Universidad de Navarra
Pamplona, Spain
Hospital Universitario de Salamanca
Salamanca, Spain
Cardiff and Vale University Health Board
Cardiff, United Kingdom
University College London Hospital NHS Foundation Trust
London, United Kingdom
The Newcastle Hospitals NHS Foundation Trust
Newcastle upon Tyne, United Kingdom
Trial contact
Medical Information
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/16/2026.
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