Non-covalent BTK Inhibitor Nemtabrutinib in Combination With the CD20 Monoclonal Antibody Rituximab for the Treatment of Marginal Zone Lymphoma
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This phase II trial tests the effect of nemtabrutinib in combination with rituximab in treating patients with marginal zone lymphoma. Nemtabrutinib, a non-covalent Bruton's tyrosine kinase (BTK) inhibitor, may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Rituximab is a monoclonal antibody. It binds to a protein called CD20, which is found on B cells (a type of white blood cell) and some types of cancer cells. This may help the immune system kill cancer cells. Giving nemtabrutinib in combination with rituximab may be safe, tolerable and/or effective in treating patients with marginal zone lymphoma.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Wyrażona świadoma zgoda pacjenta lub jego prawnego opiekuna.
- •Osoby w wieku 18 lat lub starsze.
- •Zdiagnozowany chłoniak strefy brzeżnej (każdego rodzaju), potwierdzony badaniem histopatologicznym.
- •Pacjent wymaga leczenia chłoniaka strefy brzeżnej. Do badania mogą być włączeni pacjenci, którzy już byli leczeni lub nigdy nie byli leczeni.
- •Chłoniak jest widoczny na badaniach obrazowych (np. węzły chłonne lub zmiany poza węzłami) lub w przypadku niektórych typów chłoniaka (np. w śledzionie, skórze, żołądku, spojówce) po potwierdzeniu histopatologicznym i spełnieniu dodatkowych kryteriów dotyczących wielkości lub liczby zmian.
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- September 29, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (1)
City of Hope Medical Center
Duarte, United States
Trial contact
Geoffrey Shouse
Geoffrey Shouse
PRINCIPAL_INVESTIGATOR
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 9/30/2026.
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